{"id":"W3211445741","doi":"10.1182/blood-2021-145491","title":"KDM6 Demethylases Integrate DNA Repair Gene Regulation: Loss of KDM6A Sensitizes AML to PARP Inhibition and Potentiates with BCL2 Blockade","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Cancer research; Myeloid leukemia; DNA repair; Synthetic lethality; Biology; Carcinogenesis; Leukemia; Small hairpin RNA; DNA damage; PARP inhibitor; Gene knockdown; Poly ADP ribose polymerase; Cancer; Genetics; Gene; DNA; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001251191,0.000257453,0.0002462991,0.0003005854,0.0001626018,0.0003123924,0.0002002365,0.0002988549,0.003154312],"category_scores_gemma":[0.000100854,0.0001164365,0.0002752329,0.0001743349,0.0002329779,0.0001734832,0.0002045703,0.000698693,0.0007440498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003060764,"about_ca_system_score_gemma":0.0001459717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002485678,"about_ca_topic_score_gemma":0.000565881,"domain_scores_codex":[0.9998679,0.00001176977,0.00001591961,0.00003443226,0.00004049347,0.00002933025],"domain_scores_gemma":[0.9999079,0.000008509312,0.0000268216,0.00001269452,0.000008580313,0.00003550663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001990554,0.00004985563,0.0004680454,0.00004808279,0.000008599033,0.00005453292,0.000009658956,0.00006659845,0.995443,0.0001291391,0.0001867616,0.003336845],"study_design_scores_gemma":[0.00004826908,0.0004736713,0.008339323,0.000008738397,0.0000325647,0.0007666571,0.00003358986,0.0007824695,0.9793625,0.000116799,0.01002973,0.000005664177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859906,0.004745269,0.003683313,0.0003849673,0.0001191911,0.00005814698,0.001923457,0.0003482706,0.002746748],"genre_scores_gemma":[0.9922524,0.0009963994,0.001548729,0.0001123784,0.00001143613,0.00003324377,0.001263678,0.0000240131,0.003757687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003154312,"threshold_uncertainty_score":0.01055223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01144473121474179,"score_gpt":0.249036685576814,"score_spread":0.2375919543620722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}