{"id":"W3211458171","doi":"10.1158/1078-0432.ccr-21-1688","title":"Association of Neutrophil-to-Lymphocyte Ratio with Efficacy of First-Line Avelumab plus Axitinib vs. Sunitinib in Patients with Advanced Renal Cell Carcinoma Enrolled in the Phase 3 JAVELIN Renal 101 Trial","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre","funders":"National Cancer Institute; Merck KGaA; Pfizer","keywords":"Medicine; Avelumab; Axitinib; Sunitinib; Internal medicine; Renal cell carcinoma; Renal carcinoma; Oncology; Lymphocyte; Gastroenterology; Urology; Nivolumab; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002364554,0.0003739829,0.001081737,0.0001330498,0.0001667351,0.000779519,0.0003926228,0.0004715464,0.001077788],"category_scores_gemma":[0.001748044,0.0001629979,0.001101191,0.0001509466,0.0002839253,0.0005591726,0.0002373045,0.001427055,0.0001713752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004848761,"about_ca_system_score_gemma":0.0005568436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002294494,"about_ca_topic_score_gemma":0.0006957186,"domain_scores_codex":[0.9992048,0.0004650916,0.00005796314,0.0001137893,0.00008183434,0.00007644323],"domain_scores_gemma":[0.9988322,0.0003625209,0.0004059013,0.00008041807,0.00004826656,0.0002707319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7790363,0.00608477,0.1097375,0.0007107245,0.005073034,0.0001210987,0.000105249,0.002821181,0.01143605,0.0001982683,0.002226809,0.082449],"study_design_scores_gemma":[0.1890675,0.3051126,0.4735188,0.0001298741,0.005326998,0.0009525456,0.0001383044,0.01133978,0.008104387,0.0008236228,0.005395398,0.00009023015],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962074,0.002682908,0.0001275989,0.0001497924,0.00004541372,0.00008261699,0.0002051202,0.00001595435,0.0004832737],"genre_scores_gemma":[0.9987769,0.0003086231,0.0001083134,0.0001275632,0.00005336418,0.00006956484,0.0003132119,0.000002917947,0.0002396617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002364554,"threshold_uncertainty_score":0.01250511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08944128772444122,"score_gpt":0.4151911916443016,"score_spread":0.3257499039198604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}