{"id":"W3211480515","doi":"10.1182/blood-2021-148709","title":"<i>In Vivo</i> Delivery of a CD20 CAR Using a CD8-Targeted Fusosome in Southern Pig-Tail Macaques (<i>M. nemestrina</i>) Results in B Cell Depletion","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Biology; CD8; Ex vivo; In vivo; Chimeric antigen receptor; Gene delivery; T cell; Immunology; Transduction (biophysics); B cell; Cell biology; Genetic enhancement; Molecular biology; Antigen; Immune system; Antibody; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002025552,0.0004548307,0.0002280026,0.0002683472,0.0002195404,0.0002668964,0.0002757596,0.0005001268,0.001028351],"category_scores_gemma":[0.0000858584,0.0001415839,0.000269306,0.00007586792,0.0003112547,0.0002258188,0.0001652388,0.0006282622,0.0004045391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002822183,"about_ca_system_score_gemma":0.0001573411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001432048,"about_ca_topic_score_gemma":0.00161528,"domain_scores_codex":[0.9998502,0.00001920763,0.000009636848,0.00005520148,0.00002435709,0.00004139742],"domain_scores_gemma":[0.9998838,0.00001811235,0.00004448532,0.00001751496,0.00001269477,0.00002340088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001016797,0.00005893708,0.0001247473,0.00001597768,0.000003179343,0.00003479806,0.00002394545,0.00002099828,0.998889,0.00006439201,0.00004471028,0.0006176424],"study_design_scores_gemma":[0.00001681812,0.0007880397,0.002434945,0.00000633419,0.00001704823,0.000235592,0.00002491832,0.0003406957,0.9943111,0.00002868904,0.001792675,0.000003164026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911828,0.0009395357,0.004275762,0.0001465347,0.00004684865,0.00009445257,0.0004756578,0.0001993934,0.002639083],"genre_scores_gemma":[0.9895172,0.0005168419,0.004108702,0.00009874976,0.00001938159,0.0001378065,0.0005905642,0.00005369136,0.004957161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001432048,"threshold_uncertainty_score":0.003440201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02224595986032634,"score_gpt":0.2713712291972304,"score_spread":0.2491252693369041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}