{"id":"W3211486568","doi":"10.1016/j.peptides.2021.170697","title":"Apelin pathway in cardiovascular, kidney, and metabolic diseases: Therapeutic role of apelin analogs and apelin receptor agonists","year":2021,"lang":"en","type":"review","venue":"Peptides","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Institute of Population and Public Health; Heart and Stroke Foundation of Canada","keywords":"Apelin; Proteases; Context (archaeology); Pharmacology; Neprilysin; Kidney; Receptor; Internal medicine; Endocrinology; Medicine; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005310407,0.0008399748,0.001528873,0.001504486,0.0001899085,0.0009473464,0.0007303624,0.0009286241,0.003691437],"category_scores_gemma":[0.0006348562,0.0002350802,0.0005613872,0.001647663,0.0002995147,0.001038257,0.0005765856,0.002020088,0.001312083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003275044,"about_ca_system_score_gemma":0.0006530222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000585952,"about_ca_topic_score_gemma":0.001190736,"domain_scores_codex":[0.9998881,0.00001967242,0.0000187122,0.00002126502,0.00003862554,0.0000137126],"domain_scores_gemma":[0.9997755,0.0001211894,0.00003231076,0.000005763606,0.00004424949,0.00002109688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000334877,0.0001566834,0.0001428279,0.02121241,0.0002305558,0.0002296624,0.00004642687,0.0004792424,0.003401783,0.002785927,0.01847273,0.9525069],"study_design_scores_gemma":[0.0001874563,0.0005076682,0.001526908,0.005507149,0.0006796105,0.00140466,0.00009366696,0.0003295807,0.001303542,0.003120513,0.9852906,0.00004859814],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001262401,0.9990762,0.00008588812,0.0001229635,0.0001152519,0.000003662779,0.00001666212,0.000004461551,0.0004485123],"genre_scores_gemma":[0.000578074,0.9986687,0.0001650242,0.0001415178,0.000147319,0.000005250559,0.00002399489,8.302902e-7,0.0002693187],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003691437,"threshold_uncertainty_score":0.01234907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03000177782526015,"score_gpt":0.3279833573875898,"score_spread":0.2979815795623297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}