{"id":"W3211486568","doi":"10.1016/j.peptides.2021.170697","title":"Apelin pathway in cardiovascular, kidney, and metabolic diseases: Therapeutic role of apelin analogs and apelin receptor agonists","year":2021,"lang":"en","type":"review","venue":"Peptides","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Institute of Population and Public Health; Heart and Stroke Foundation of Canada","keywords":"Apelin; Proteases; Context (archaeology); Pharmacology; Neprilysin; Kidney; Receptor; Internal medicine; Endocrinology; Medicine; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001689632,0.0007859376,0.005100085,0.0007618856,0.00008033627,0.0000706647,0.0003478262,0.0008709719,0.0004118879],"category_scores_gemma":[0.002586686,0.0005948129,0.001286556,0.001356981,0.0007200685,0.00009021432,0.0004399314,0.001403108,0.00009943538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001486814,"about_ca_system_score_gemma":0.002098874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002682926,"about_ca_topic_score_gemma":0.00001866368,"domain_scores_codex":[0.9941718,0.000947226,0.001472298,0.001253041,0.001302012,0.0008536389],"domain_scores_gemma":[0.996318,0.0008301918,0.0003188306,0.001065837,0.0002780763,0.00118901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004656264,0.0002653969,0.0002888647,0.01331927,0.002141991,0.0001464656,0.0001456598,2.292413e-7,0.0001379421,0.0001042211,0.0002882789,0.9831151],"study_design_scores_gemma":[0.0013998,0.0001460096,0.0006341473,0.01812567,0.003151033,0.0001032967,0.0002498279,0.00005512566,0.00003783739,0.0001068688,0.9754695,0.0005208964],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007505618,0.9966704,0.00001842808,0.0001788978,0.0001375242,0.001577502,0.0003271311,0.0000478636,0.000291731],"genre_scores_gemma":[0.001628913,0.9957322,0.0004033069,0.0001918848,0.0003693003,0.0001937024,0.0008453426,0.0001425007,0.0004928233],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9825942,"threshold_uncertainty_score":0.9996503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03000177782526015,"score_gpt":0.3279833573875898,"score_spread":0.2979815795623297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}