{"id":"W3211512869","doi":"10.1101/2021.11.05.467407","title":"ACPA-IgG variable domain glycosylation increases before the onset of rheumatoid arthritis and stabilizes thereafter; a cross-sectional study encompassing over 1500 samples","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Dutch Arthritis Association; Reumatikerförbundet; Leids Universitair Medisch Centrum; Umeå Universitet; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Vetenskapsrådet; ZonMw","keywords":"Rheumatoid arthritis; Immunology; Medicine; Antibody; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006772382,0.0002618768,0.0002309766,0.0006293242,0.0004310444,0.0005360043,0.0002147583,0.0004160604,0.001230632],"category_scores_gemma":[0.001046661,0.0003157056,0.0002350769,0.0005438754,0.0002702892,0.0003583126,0.0002840829,0.0003663085,0.0003548265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002000684,"about_ca_system_score_gemma":0.0001375637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00281173,"about_ca_topic_score_gemma":0.002850335,"domain_scores_codex":[0.9995224,0.0001001778,0.00004418782,0.0001906364,0.00008192494,0.00006062466],"domain_scores_gemma":[0.999285,0.0001231744,0.0002379065,0.00007609484,0.0001348748,0.0001429783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000117464,0.00002532222,0.9978581,0.000006462737,0.00004201489,0.0000429891,0.00009884329,0.000009191115,0.0009312063,0.000005897164,0.00003800887,0.0008244718],"study_design_scores_gemma":[0.00000307537,0.0001042419,0.999167,0.000002058548,0.00001981973,0.0002775408,0.00009508138,0.00003484275,0.0001385357,0.000003651584,0.0001530355,0.000001178198],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994091,0.0001543283,0.00008102882,0.00000545234,0.000002380636,0.000005181397,0.0001508586,0.000002540216,0.0001892382],"genre_scores_gemma":[0.9994379,0.00005162751,0.00007935588,0.00001047553,0.000003861067,0.000006368556,0.0002237094,0.000001755291,0.0001850396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00281173,"threshold_uncertainty_score":0.005590737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02105158430850022,"score_gpt":0.2788612449909956,"score_spread":0.2578096606824953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}