{"id":"W3211544433","doi":"10.1182/blood-2021-151313","title":"Impact of Age, Body Surface Area, and Body Mass Index on Pegaspargase Toxicity and Pharmacokinetics: A Report from the DFCI ALL Consortium","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Childhood Cancer Survivors' Quality of Life","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McMaster University","funders":"","keywords":"Medicine; Body surface area; Body mass index; Toxicity; Asparaginase; Internal medicine; Gastroenterology; Pharmacokinetics; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01348904,0.0004919715,0.001065967,0.0005329446,0.0002734504,0.001022389,0.0004751198,0.0005169435,0.001131232],"category_scores_gemma":[0.01458901,0.0001897473,0.000991077,0.001292848,0.0002947129,0.0005147296,0.0004868309,0.00071719,0.0002112399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001139727,"about_ca_system_score_gemma":0.001205798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003260551,"about_ca_topic_score_gemma":0.00317306,"domain_scores_codex":[0.9958978,0.002061387,0.0004841762,0.0003068742,0.001090696,0.0001590196],"domain_scores_gemma":[0.9791492,0.01060379,0.00503812,0.001144473,0.003236802,0.0008276494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02894542,0.0007628531,0.7409996,0.0008125588,0.00254477,0.0003670679,0.000409423,0.001057981,0.005723841,0.0001932888,0.01201265,0.2061705],"study_design_scores_gemma":[0.003288654,0.01345138,0.9462563,0.0002834888,0.003444157,0.001140796,0.0002669908,0.0009592441,0.004978786,0.0001183,0.02571449,0.00009732351],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9590158,0.02414558,0.0009204227,0.002431949,0.00008275293,0.0005504378,0.005307189,0.00005004641,0.007495783],"genre_scores_gemma":[0.9869054,0.006231978,0.000748315,0.001413621,0.000251292,0.0002503832,0.00348133,0.00002783269,0.0006897312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01348904,"threshold_uncertainty_score":0.0713377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03065556108493981,"score_gpt":0.3327119917516591,"score_spread":0.3020564306667193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}