{"id":"W3211568008","doi":"10.1038/s41467-021-26949-7","title":"Identifying regulators of parental imprinting by CRISPR/Cas9 screening in haploid human embryonic stem cells","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation; Rosetrees Trust","keywords":"Genomic imprinting; Biology; Imprinting (psychology); CRISPR; Genetics; DNA methylation; Epigenetics; Differentially methylated regions; Embryonic stem cell; Histone; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000256931,0.0002398023,0.000284197,0.0002718281,0.0001370927,0.0003533411,0.0002874934,0.0002328655,0.001618113],"category_scores_gemma":[0.0002111776,0.0002262978,0.0002177291,0.0001594611,0.0002031903,0.0001160043,0.0002437878,0.0003941403,0.0004442164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003302261,"about_ca_system_score_gemma":0.0002740439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009777835,"about_ca_topic_score_gemma":0.00169314,"domain_scores_codex":[0.9997631,0.00002065102,0.00002993707,0.00007157012,0.00008821758,0.0000265572],"domain_scores_gemma":[0.9998714,0.00003914084,0.00003549971,0.00002277466,0.00001282721,0.00001829468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002765483,0.000006613,0.0003246657,0.00002522544,0.000004279114,0.00004442559,0.00001071177,0.0001154829,0.9976686,0.00008807197,0.0000307522,0.001653588],"study_design_scores_gemma":[0.000007777177,0.00004690476,0.002673304,0.000002964641,0.00001152292,0.0001158813,0.00001691637,0.001489164,0.9938256,0.00003410214,0.001772071,0.000003904544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.961449,0.001195585,0.03098643,0.0001447565,0.00004266232,0.0001678872,0.002604178,0.0005926666,0.002816852],"genre_scores_gemma":[0.971063,0.0007679098,0.02152893,0.00008788514,0.000005217786,0.0001100942,0.002090451,0.0001111576,0.004235435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001618113,"threshold_uncertainty_score":0.005413115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02426622359595051,"score_gpt":0.3225251069570754,"score_spread":0.2982588833611249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}