{"id":"W3211572770","doi":"10.1182/blood-2021-145362","title":"Impact of <i>FLT3</i> Mutation Clearance after Front-Line Treatment with Gilteritinib Plus Azacitidine, or Gilteritinib or Azacitidine Alone in Patients with Newly Diagnosed AML: Results from the Phase 2/3 Lacewing Trial","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Azacitidine; Internal medicine; Surgery; Gastroenterology; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00244119,0.0007612018,0.001652329,0.0002100409,0.0002674249,0.001171056,0.0006193048,0.000814955,0.00117257],"category_scores_gemma":[0.001364161,0.000201679,0.002201169,0.0002090425,0.0005870098,0.0008847826,0.0003565783,0.002311657,0.0002054213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000912939,"about_ca_system_score_gemma":0.0009240452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008310724,"about_ca_topic_score_gemma":0.002094892,"domain_scores_codex":[0.9993262,0.0003300908,0.00004677801,0.0001304265,0.00005418008,0.0001122566],"domain_scores_gemma":[0.9986345,0.0003386233,0.0003533962,0.00007706624,0.00005585827,0.0005404603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8891337,0.007208905,0.03122099,0.0003526569,0.002671315,0.0001347779,0.0001235521,0.001902486,0.009455079,0.000095887,0.001469166,0.05623145],"study_design_scores_gemma":[0.35995,0.4657399,0.1551268,0.00009644382,0.006223551,0.0005062643,0.0001270751,0.004390705,0.005069258,0.0004772595,0.002208507,0.00008421243],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970217,0.001769249,0.0000946912,0.0002073533,0.00004333527,0.0001072176,0.000295669,0.00001928957,0.0004414013],"genre_scores_gemma":[0.9980341,0.0004433839,0.0001547602,0.0002717598,0.00008258728,0.00009176956,0.0006654428,0.000005492731,0.0002507901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00244119,"threshold_uncertainty_score":0.01291037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02904121435726879,"score_gpt":0.3147635671479772,"score_spread":0.2857223527907083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}