{"id":"W3211588580","doi":"10.14283/jpad.2022.49","title":"Prediction of Cognitive Decline for Enrichment of Alzheimer's Disease Clinical Trials","year":2022,"lang":"en","type":"preprint","venue":"The Journal of Prevention of Alzheimer s Disease","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Douglas College","funders":"National Institute on Aging","keywords":"Disease; Clinical trial; Cognition; Cognitive decline; Demographics; Alzheimer's disease; Sample size determination; Cognitive impairment; Medicine; Psychology; Gerontology; Internal medicine; Demography; Dementia; Psychiatry; Statistics; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1133694,0.001223412,0.002817154,0.002211096,0.0005536062,0.002704896,0.001536502,0.001498571,0.003657635],"category_scores_gemma":[0.2021247,0.0005590621,0.002891645,0.001635746,0.000941826,0.00256144,0.001842716,0.002566775,0.0009001348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001368466,"about_ca_system_score_gemma":0.003996457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009680184,"about_ca_topic_score_gemma":0.001615881,"domain_scores_codex":[0.9434383,0.04793081,0.003141416,0.002368539,0.002446255,0.0006747106],"domain_scores_gemma":[0.7521632,0.2079143,0.02173929,0.007435284,0.007401326,0.003346647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.02350573,0.001144006,0.5234982,0.002748881,0.004730227,0.0003899928,0.0004971157,0.1001142,0.0006941668,0.004632534,0.02290501,0.31514],"study_design_scores_gemma":[0.005346154,0.007849828,0.1493611,0.002073668,0.003745838,0.0005751267,0.0001714022,0.7770824,0.001834296,0.03445807,0.01730764,0.0001946284],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5773623,0.0198038,0.344595,0.02118123,0.000934122,0.01273146,0.007694086,0.002897042,0.01280093],"genre_scores_gemma":[0.9242861,0.001150766,0.06648594,0.001245511,0.0003246673,0.00322985,0.002379152,0.00007982765,0.000818075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1133694,"threshold_uncertainty_score":0.599562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2062643494493087,"score_gpt":0.478324773316448,"score_spread":0.2720604238671393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}