{"id":"W3211600372","doi":"10.1002/jcb.30173","title":"Review of cancer cell resistance mechanisms to apoptosis and actual targeted therapies","year":2021,"lang":"en","type":"review","venue":"Journal of Cellular Biochemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Apoptosis; Cancer research; Mechanism (biology); Cancer; Medicine; Biology; Internal medicine; Genetics; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000485891,0.0004037052,0.001403312,0.0000525448,0.00004479761,0.00002308264,0.0003303779,0.0004738845,0.00008155465],"category_scores_gemma":[0.00009926948,0.0003221003,0.000691607,0.0001755399,0.00004488129,0.000004794315,0.0001484053,0.000215562,6.205585e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005585612,"about_ca_system_score_gemma":0.0004975913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000377766,"about_ca_topic_score_gemma":0.000001881865,"domain_scores_codex":[0.9978526,0.0001103358,0.001118853,0.0003982439,0.0003063138,0.0002137071],"domain_scores_gemma":[0.9974634,0.00002442968,0.001441721,0.0004613925,0.0004297144,0.0001793415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002923577,0.00006723259,5.911933e-8,0.06238754,0.0003766494,0.000006951746,0.00001765887,5.295603e-7,0.8484482,0.000009814768,0.004737415,0.08391867],"study_design_scores_gemma":[0.0001367451,0.00007228069,3.763749e-8,0.03305282,0.0004504772,0.00001829699,0.00002571729,9.165542e-8,0.4996048,0.000007514703,0.4664225,0.0002086711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002529942,0.997759,0.001208018,0.0000532752,0.0002431519,0.0002479467,0.0001189424,0.000002596938,0.0001140361],"genre_scores_gemma":[0.0001847245,0.9939973,0.00353639,0.0001270497,0.0003592229,0.00001533796,0.0002491658,0.00005480204,0.001476016],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4616851,"threshold_uncertainty_score":0.9999231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01214676014502876,"score_gpt":0.2850731324883608,"score_spread":0.2729263723433321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}