{"id":"W3211606478","doi":"10.2139/ssrn.3959283","title":"Genetic Association and Mendelian Randomization for Hypothyroidism Highlight Immune Molecular Mechanisms","year":2021,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Mendelian randomization; Mendelian inheritance; Genetic association; Association (psychology); Genome-wide association study; Genetics; Biology; Immune system; Computational biology; Evolutionary biology; Medicine; Bioinformatics; Psychology; Single-nucleotide polymorphism; Gene; Genetic variants; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002311361,0.0008565644,0.0007732192,0.001951558,0.0003962345,0.0006887547,0.0009543397,0.001030454,0.008515412],"category_scores_gemma":[0.004986626,0.0003460366,0.0009951896,0.001125892,0.0009474832,0.0005298268,0.0006257247,0.0007194781,0.0004181861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003217824,"about_ca_system_score_gemma":0.0003335324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001031285,"about_ca_topic_score_gemma":0.0009473329,"domain_scores_codex":[0.9965568,0.001471916,0.0002055359,0.0009627694,0.0005500292,0.0002529804],"domain_scores_gemma":[0.9949591,0.003178565,0.0007782559,0.0007240811,0.0001316667,0.000228275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01309723,0.0003766995,0.5465426,0.0003607318,0.003683393,0.01748682,0.0009048505,0.002905748,0.304534,0.03749932,0.002325226,0.07028323],"study_design_scores_gemma":[0.0008294831,0.001014238,0.8824029,0.00009758211,0.002045093,0.02474079,0.0003561541,0.01851901,0.02446468,0.04131779,0.004054236,0.000158012],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722371,0.001303364,0.02072469,0.001060182,0.000131499,0.00003431639,0.0005925375,0.0002941374,0.003622266],"genre_scores_gemma":[0.9950877,0.0001788783,0.003524399,0.0001221418,0.00009615916,0.0000147393,0.0001256508,0.00004656828,0.0008037826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008515412,"threshold_uncertainty_score":0.02848691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003399636430888362,"score_gpt":0.2042337427133971,"score_spread":0.2008341062825087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}