{"id":"W3211611146","doi":"10.1111/ejh.13726","title":"Kinetics of response to first‐ and second‐line therapies in multiple myeloma: Assessment by both M‐spikes and light chains","year":2021,"lang":"en","type":"article","venue":"European Journal Of Haematology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Lenalidomide; Oncology; Medicine; Cohort; Multiple myeloma; Bortezomib; Internal medicine; Immunoglobulin light chain; Dexamethasone; Cyclophosphamide; Clearance; Melphalan; Complete response; Kinetics; Immunology; Chemotherapy; Urology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005894857,0.0001313024,0.000545901,0.0002257751,0.00003232295,0.00001428007,0.00007316274,0.0000303931,0.00008876222],"category_scores_gemma":[0.0005379189,0.00009930691,0.00004772161,0.0001288844,0.00009643636,0.00004312924,0.00009440345,0.0002073998,0.000002611523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002934112,"about_ca_system_score_gemma":0.00005837293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002999914,"about_ca_topic_score_gemma":0.00006280763,"domain_scores_codex":[0.9982441,0.000679032,0.0005078583,0.0001657525,0.0001881225,0.0002151469],"domain_scores_gemma":[0.9988946,0.0003760341,0.0001738903,0.0001651715,0.0001537059,0.0002365417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00777744,0.001574382,0.3394836,0.0004526284,0.0005316048,0.05825511,0.004499268,0.000009040294,0.5726916,0.0001138363,0.003757003,0.01085446],"study_design_scores_gemma":[0.01329717,0.005007253,0.8747924,0.0004674925,0.0000642461,0.01240862,0.001130052,0.0001267158,0.06924617,0.00002314135,0.02327233,0.0001644045],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864155,0.004423304,0.0003748586,0.008261135,0.00005046,0.0001474851,0.00001704216,0.000004322713,0.0003058699],"genre_scores_gemma":[0.9940423,0.0005150483,0.004823859,0.0002046341,0.00002786397,0.000001542418,0.000004218953,0.00002183783,0.0003587455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5353088,"threshold_uncertainty_score":0.4049618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02310429410495675,"score_gpt":0.3006644771747745,"score_spread":0.2775601830698178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}