{"id":"W3211621704","doi":"10.1182/blood-2021-146393","title":"Real-World Outcomes for Pediatric and Young Adult Patients with Relapsed or Refractory (R/R) B-Cell Acute Lymphoblastic Leukemia (ALL) Treated with Tisagenlecleucel: Update from the Center for International Blood and Marrow Transplant Research (CIBMTR) Registry","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Internal medicine; Cytokine release syndrome; Single Center; Clinical trial; Refractory (planetary science); Hematopoietic stem cell transplantation; Oncology; Pediatrics; Immunotherapy; Transplantation; Chimeric antigen receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002740321,0.0002992141,0.0006969895,0.001135238,0.0002801864,0.001288905,0.000702402,0.0004349636,0.001180066],"category_scores_gemma":[0.005803693,0.000223449,0.0008327354,0.002561386,0.0003367133,0.0009313897,0.0007317296,0.0008324918,0.000384498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009652104,"about_ca_system_score_gemma":0.0007967702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004355357,"about_ca_topic_score_gemma":0.007364211,"domain_scores_codex":[0.99805,0.0006560641,0.0003450607,0.0003057984,0.0004811715,0.0001620021],"domain_scores_gemma":[0.9906257,0.001262126,0.005834238,0.000500328,0.001069232,0.0007083926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001457243,0.00007828026,0.9838108,0.0002163175,0.0005644446,0.00006875111,0.0001077592,0.0002095134,0.0001219365,0.0001198126,0.003952806,0.009292377],"study_design_scores_gemma":[0.0002048242,0.0004050148,0.993412,0.0001093677,0.0004647417,0.0004453993,0.0002141262,0.0002252112,0.00015669,0.00008764637,0.004251996,0.00002307443],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9315338,0.007918399,0.0007441119,0.0006872817,0.00005701404,0.0001604324,0.05569102,0.00006158718,0.003146467],"genre_scores_gemma":[0.942414,0.003162888,0.0009445985,0.0004090455,0.00008829279,0.0003013533,0.05232491,0.00002614494,0.0003286729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004355357,"threshold_uncertainty_score":0.01449239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0201699544481447,"score_gpt":0.2896246359916098,"score_spread":0.2694546815434651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}