{"id":"W3211621704","doi":"10.1182/blood-2021-146393","title":"Real-World Outcomes for Pediatric and Young Adult Patients with Relapsed or Refractory (R/R) B-Cell Acute Lymphoblastic Leukemia (ALL) Treated with Tisagenlecleucel: Update from the Center for International Blood and Marrow Transplant Research (CIBMTR) Registry","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Internal medicine; Cytokine release syndrome; Single Center; Clinical trial; Refractory (planetary science); Hematopoietic stem cell transplantation; Oncology; Pediatrics; Immunotherapy; Transplantation; Chimeric antigen receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003194261,0.0003086278,0.0004399505,0.0001828309,0.0002134236,0.0001270856,0.0002326298,0.0001372765,0.000158483],"category_scores_gemma":[0.0002456113,0.0001809526,0.00008677944,0.0003302635,0.0001759843,0.0001213003,0.00007387865,0.0003884119,0.000002654769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001523326,"about_ca_system_score_gemma":0.0005124752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004492428,"about_ca_topic_score_gemma":0.001834227,"domain_scores_codex":[0.997374,0.0001392025,0.0003702367,0.0007396265,0.0008107192,0.0005662034],"domain_scores_gemma":[0.9968675,0.00104632,0.0001334867,0.0005474341,0.001160201,0.000245063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01430879,0.001429325,0.9718146,0.0002427807,0.00173592,0.000350363,0.0005042157,4.434006e-7,0.007248244,0.00001469981,0.001800767,0.0005498097],"study_design_scores_gemma":[0.1835711,0.005475044,0.7735795,0.0006282557,0.00588995,0.0002247313,0.0004035908,0.0002105679,0.02381192,0.00006304908,0.005331201,0.0008111357],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950242,0.0001757154,0.00003153255,0.0005543951,0.0001229337,0.001615268,0.001866161,0.00004799099,0.0005617964],"genre_scores_gemma":[0.9797805,0.002682773,0.001783711,0.0002679608,0.0003945107,0.0003742249,0.002214779,0.0001363576,0.0123652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1982352,"threshold_uncertainty_score":0.7379032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0201699544481447,"score_gpt":0.2896246359916098,"score_spread":0.2694546815434651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}