{"id":"W3211623221","doi":"10.1016/s0140-6736(21)01751-7","title":"Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":242,"is_retracted":false,"has_abstract":false,"ca_institutions":"LMC Diabetes & Endocrinology (Canada); Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Novo Nordisk Fonden; Novo Nordisk; National Institute for Health and Care Research","keywords":"Medicine; Overweight; Placebo; Physical therapy; Double blind; Obesity; Weight management; Randomized controlled trial; Weight loss; Internal medicine; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007135012,0.0003134747,0.001630925,0.0001435762,0.0001541854,0.0001170444,0.0001072113,0.00006424807,0.00005172704],"category_scores_gemma":[0.0000676009,0.0001816638,0.0001563422,0.0002056989,0.00005958962,0.0001294133,0.00009792663,0.0001599916,0.000004151771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000995553,"about_ca_system_score_gemma":0.00005377356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002912811,"about_ca_topic_score_gemma":0.0003998094,"domain_scores_codex":[0.9982113,0.0001276782,0.0004061444,0.0004807674,0.0002702563,0.0005038875],"domain_scores_gemma":[0.9985989,0.0006223652,0.0001895378,0.0004111053,0.00005767757,0.0001204311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9856654,0.001113673,0.001292441,0.0002235283,0.002456896,0.0001671806,0.0006569035,0.000007579038,0.00007930167,0.001341681,0.0007361859,0.006259203],"study_design_scores_gemma":[0.987291,0.0007534751,0.001108893,0.0001883883,0.002805549,0.00001000138,0.0006747037,0.001442248,0.0003869215,0.0001277589,0.00500052,0.0002105],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726177,0.001091848,0.0001447246,0.003641637,0.0001989773,0.01511036,0.00001689712,0.00004863174,0.007129245],"genre_scores_gemma":[0.981116,0.001590412,0.001935166,0.0006783314,0.0007710996,0.003887962,0.0001008834,0.00004547677,0.009874667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01122239,"threshold_uncertainty_score":0.7408034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02776963828315758,"score_gpt":0.300815709648638,"score_spread":0.2730460713654804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}