{"id":"W3211623221","doi":"10.1016/s0140-6736(21)01751-7","title":"Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":242,"is_retracted":false,"has_abstract":false,"ca_institutions":"LMC Diabetes & Endocrinology (Canada); Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Novo Nordisk Fonden; Novo Nordisk; National Institute for Health and Care Research","keywords":"Medicine; Overweight; Placebo; Physical therapy; Double blind; Obesity; Weight management; Randomized controlled trial; Weight loss; Internal medicine; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002395213,0.003036731,0.005052167,0.0006902855,0.0007198605,0.001603195,0.001259147,0.003508146,0.009396073],"category_scores_gemma":[0.002592819,0.0012087,0.003279417,0.0005525298,0.001358834,0.001710169,0.0007456256,0.004380731,0.001682776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008379244,"about_ca_system_score_gemma":0.001001365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001981559,"about_ca_topic_score_gemma":0.003865025,"domain_scores_codex":[0.9991178,0.0004027508,0.00005507599,0.0001975301,0.00007819595,0.0001486686],"domain_scores_gemma":[0.9990815,0.0002612013,0.0002086407,0.00009277641,0.00006749641,0.0002883819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9888149,0.002200894,0.0001699806,0.0007424401,0.0009603139,0.00002304484,0.0000371376,0.00009868326,0.001126804,0.00006145162,0.0006342973,0.005130148],"study_design_scores_gemma":[0.9903582,0.008605381,0.0004025293,0.00002289053,0.0002627662,0.000008642616,0.000009696363,0.00006897092,0.00005525335,0.00004551831,0.0001529098,0.000007223311],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658207,0.01363256,0.001913747,0.002317416,0.002605982,0.00688563,0.002554037,0.0004425082,0.003827428],"genre_scores_gemma":[0.9588675,0.008217731,0.004362033,0.004503225,0.001739902,0.01068717,0.002003459,0.000125897,0.009493181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009396073,"threshold_uncertainty_score":0.03143299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02776963828315758,"score_gpt":0.300815709648638,"score_spread":0.2730460713654804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}