{"id":"W3211628515","doi":"10.25251/skin.5.supp.42","title":"Once-Daily Roflumilast Cream 0.3%, a Potent Phosphodiesterase-4 Inhibitor, Provided Safe and Effective Treatment of Psoriasis in the DERMIS-1 and DERMIS-2 Phase 3 Trials","year":2021,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"","keywords":"Roflumilast; Dermis; Psoriasis; Medicine; Pharmacology; Phosphodiesterase inhibitor; Dermatology; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001015471,0.0001867071,0.0005315599,0.00005959343,0.00009015379,0.00001519299,0.00008384697,0.00009342413,0.00001450886],"category_scores_gemma":[0.0007868715,0.00008954258,0.0001011691,0.0001162789,0.0002058161,0.000007567716,0.00002673731,0.0001060582,2.1831e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000384579,"about_ca_system_score_gemma":0.0001141268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003805788,"about_ca_topic_score_gemma":0.00008178385,"domain_scores_codex":[0.9980171,0.0007467144,0.0006736135,0.0001614998,0.0002565132,0.0001445111],"domain_scores_gemma":[0.9984088,0.0005918856,0.0005058309,0.0002070108,0.0002074699,0.00007903334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01041201,0.00151267,0.001377068,0.0001297824,0.00078221,0.0007834822,0.01125846,0.0001369168,0.7550809,0.00002226122,0.003915476,0.2145887],"study_design_scores_gemma":[0.02179771,0.01590803,0.003441083,0.0005715493,0.001048461,0.02036591,0.00735194,0.00009918057,0.8971017,0.000322338,0.03172624,0.0002658324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797246,0.01653105,0.000219181,0.00257047,0.0003389136,0.0004594406,0.000009357431,0.000001768131,0.0001452303],"genre_scores_gemma":[0.9911585,0.007651573,0.00007750999,0.0003753931,0.0005005593,0.000009928881,0.00001381926,0.00001145736,0.0002012227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2143229,"threshold_uncertainty_score":0.365144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01646162550159773,"score_gpt":0.301729772481566,"score_spread":0.2852681469799683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}