{"id":"W3211628515","doi":"10.25251/skin.5.supp.42","title":"Once-Daily Roflumilast Cream 0.3%, a Potent Phosphodiesterase-4 Inhibitor, Provided Safe and Effective Treatment of Psoriasis in the DERMIS-1 and DERMIS-2 Phase 3 Trials","year":2021,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"","keywords":"Roflumilast; Dermis; Psoriasis; Medicine; Pharmacology; Phosphodiesterase inhibitor; Dermatology; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007728759,0.0004840409,0.0008454609,0.0002574135,0.000331063,0.0003883731,0.0003204315,0.0006836193,0.009687566],"category_scores_gemma":[0.0004440744,0.0001856616,0.0006800033,0.0001643471,0.0002455942,0.0003710517,0.0001353151,0.001307111,0.001547021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003410926,"about_ca_system_score_gemma":0.0005380248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008401874,"about_ca_topic_score_gemma":0.00283178,"domain_scores_codex":[0.9997665,0.00009895596,0.00001218296,0.00003224183,0.00003810089,0.00005204234],"domain_scores_gemma":[0.9998088,0.0000433273,0.00003475502,0.00002043877,0.00002512228,0.00006751541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2978202,0.01789833,0.001715629,0.002125705,0.001221483,0.0003043517,0.00008949757,0.0008510337,0.1462298,0.001059086,0.03405186,0.4966331],"study_design_scores_gemma":[0.5022737,0.361107,0.01993853,0.0003790321,0.001149339,0.001133212,0.00007911962,0.001724885,0.03661013,0.001140325,0.07440832,0.00005642375],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8733304,0.03312659,0.005999329,0.004819521,0.00172751,0.006752136,0.007105618,0.001345773,0.06579323],"genre_scores_gemma":[0.9587799,0.009309347,0.00264677,0.001768403,0.0003450681,0.001651889,0.003014472,0.00007600603,0.02240807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009687566,"threshold_uncertainty_score":0.03240818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01646162550159773,"score_gpt":0.301729772481566,"score_spread":0.2852681469799683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}