{"id":"W3211655359","doi":"10.1021/acssynbio.1c00420","title":"Engineering Yeast for <i>De Novo</i> Synthesis of the Insect Repellent Nepetalactone","year":2021,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada; Concordia University","keywords":"Geraniol; Biology; Monoterpene; Biochemistry; Saccharomyces cerevisiae; Yeast; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002452536,0.000169505,0.0002274285,0.00001750772,0.00006112814,0.000007595442,0.0003071212,0.0002865596,0.00002738386],"category_scores_gemma":[0.001231119,0.0001295489,0.0002080402,0.00009169309,0.0001263929,0.000001567546,0.0001638523,0.00008252769,0.000003234225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001420135,"about_ca_system_score_gemma":0.000132119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006635077,"about_ca_topic_score_gemma":0.000008935583,"domain_scores_codex":[0.9989439,0.00007980847,0.0002417583,0.0003717781,0.0000586556,0.0003040542],"domain_scores_gemma":[0.9990541,0.0001561199,0.0001060763,0.0005475885,0.00008211216,0.00005403621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005729523,0.0000720975,0.0005294483,0.00006570458,0.00009471609,0.000002082724,0.0000126452,0.00001835546,0.9970823,0.0001575648,0.0002245081,0.001683261],"study_design_scores_gemma":[0.0001495662,0.00004243254,0.000306866,0.00004912539,0.00006029639,0.000185935,0.00002354969,0.00002892751,0.9622887,0.00004358211,0.03666576,0.0001552456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964573,0.0005999911,0.0007894101,0.0006835071,0.0002099971,0.0001375462,0.0003327518,0.00001246391,0.0007770353],"genre_scores_gemma":[0.99816,0.0001954941,0.0007906498,0.0001709783,0.0001492417,0.00004476966,0.00005068635,0.00001949054,0.0004186973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03644126,"threshold_uncertainty_score":0.5282851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009320538851061362,"score_gpt":0.2086887174945276,"score_spread":0.1993681786434662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}