{"id":"W3211681446","doi":"10.26434/chemrxiv.14558121.v1","title":"The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Caffeine and Istradefylline","year":2021,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Aventis Foundation; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; McGill University; Genentech; Bayer; Pfizer","keywords":"Nuclear receptor; Repressor; Orphan receptor; Receptor; Chemistry; Transcription factor; Cell biology; Biology; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003746821,0.0003561357,0.0003870626,0.00007498852,0.0005193131,0.0005403936,0.0005902998,0.000272072,0.001738493],"category_scores_gemma":[0.0007781708,0.0002891467,0.0002148905,0.0002234346,0.0002480609,0.00008288516,0.0005330603,0.0008120647,0.0001412206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006984468,"about_ca_system_score_gemma":0.0001035185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002107286,"about_ca_topic_score_gemma":0.000004171497,"domain_scores_codex":[0.9973182,0.0002012593,0.0004197494,0.001178871,0.0004696582,0.0004122783],"domain_scores_gemma":[0.9983857,0.0003184923,0.0001591385,0.000752927,0.0001177913,0.0002659224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002239813,0.00005247509,0.00001362091,0.00006028717,0.00002362489,0.00002652487,0.002108893,0.00002301021,0.9852415,0.0009439758,0.009800273,0.001481812],"study_design_scores_gemma":[0.0003316191,0.00007659428,0.0002653958,0.0002443878,0.0000382233,0.0000346056,0.0004065233,0.0003311309,0.6200453,0.0003813698,0.3773467,0.0004982062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856385,0.0007069113,0.00005589685,0.01092922,0.001079111,0.0004678311,0.0000528176,0.0001130694,0.0009566532],"genre_scores_gemma":[0.9879557,0.001275107,0.001136424,0.003749181,0.0005946503,0.00004174918,0.00002114191,0.0001194327,0.005106605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3675464,"threshold_uncertainty_score":0.9999561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03724060276666556,"score_gpt":0.268017615684192,"score_spread":0.2307770129175264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}