{"id":"W3211681446","doi":"10.26434/chemrxiv.14558121.v1","title":"The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Caffeine and Istradefylline","year":2021,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Aventis Foundation; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; McGill University; Genentech; Bayer; Pfizer","keywords":"Nuclear receptor; Repressor; Orphan receptor; Receptor; Chemistry; Transcription factor; Cell biology; Biology; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001114198,0.0001928749,0.0003014173,0.0001335672,0.0001783458,0.0002620369,0.0001633785,0.0002288667,0.001887886],"category_scores_gemma":[0.000141737,0.0001265961,0.000293332,0.0001064637,0.0002544483,0.0001515009,0.0002656033,0.0002539282,0.0005033315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003344746,"about_ca_system_score_gemma":0.0001861789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007748628,"about_ca_topic_score_gemma":0.001508536,"domain_scores_codex":[0.9998569,0.00002407757,0.000008483387,0.00004071184,0.00003465603,0.0000351261],"domain_scores_gemma":[0.9999167,0.00001040891,0.000035731,0.00001038886,0.000007632742,0.00001907577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009012893,0.000003109316,0.00007463227,0.00001508244,0.000002497991,0.00002678572,0.000008741158,0.00002025314,0.9993011,0.0000576801,0.00002773307,0.0003721366],"study_design_scores_gemma":[0.00001402724,0.0001223539,0.005382806,0.000006325355,0.000006997965,0.000197057,0.0000364605,0.0005095429,0.9908043,0.00004381401,0.002870066,0.000006321652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906728,0.002953652,0.00271318,0.0002626981,0.0000406781,0.00001919124,0.0003904614,0.0001255292,0.002821926],"genre_scores_gemma":[0.9899278,0.0009380043,0.00173278,0.0001332736,0.00001349951,0.00003354583,0.0008952343,0.00007980803,0.006245914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001887886,"threshold_uncertainty_score":0.006315589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03724060276666556,"score_gpt":0.268017615684192,"score_spread":0.2307770129175264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}