{"id":"W3211706716","doi":"10.1111/acel.13514","title":"Adiponectin alleviated Alzheimer‐like pathologies via autophagy‐lysosomal activation","year":2021,"lang":"en","type":"article","venue":"Aging Cell","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Natural Science Foundation of China","keywords":"Autophagy; Neuroinflammation; Adiponectin; AMPK; PI3K/AKT/mTOR pathway; Biology; Signal transduction; Cell biology; Endocrinology; Cancer research; Internal medicine; Medicine; Phosphorylation; Inflammation; Immunology; Protein kinase A; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001572382,0.0003823095,0.000324863,0.0003294327,0.0001387319,0.0002049487,0.0001526126,0.0002102613,0.0006967441],"category_scores_gemma":[0.00005899961,0.0001185983,0.0003054846,0.0001624062,0.0002014505,0.0002463376,0.0002087381,0.0006383419,0.0001191842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001273735,"about_ca_system_score_gemma":0.0001580289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003224193,"about_ca_topic_score_gemma":0.0008073132,"domain_scores_codex":[0.9999139,0.00001415987,0.0000177381,0.00001879897,0.0000167438,0.00001868269],"domain_scores_gemma":[0.9999571,0.000002943915,0.00001638509,0.000006036847,0.000007203576,0.00001040177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00153853,0.0002930166,0.0006968479,0.0002945433,0.00004501405,0.0001530655,0.00003832126,0.00009419808,0.9867151,0.000188437,0.0001518503,0.009791003],"study_design_scores_gemma":[0.000392412,0.006358897,0.031832,0.00009914182,0.0002784495,0.000702046,0.0001483868,0.001608073,0.9490525,0.0004680215,0.009034541,0.00002545442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896379,0.005332269,0.003291847,0.000198964,0.00009344875,0.00004391876,0.0003801611,0.0001043652,0.000917132],"genre_scores_gemma":[0.9902329,0.004141047,0.002658995,0.000196479,0.00003452774,0.00006411545,0.0004111498,0.00001625273,0.002244523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006967441,"threshold_uncertainty_score":0.00233084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02173107136571244,"score_gpt":0.2766059209368196,"score_spread":0.2548748495711071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}