{"id":"W3211737035","doi":"10.1182/blood-2021-152697","title":"A Phase 3, Randomized, Double-Blinded Study of Four-Factor Prothrombin Complex Concentrate in Patients with Acute Major Bleeding on Direct Oral Anticoagulant Therapy with Factor Xa Inhibitor: The Lex-210 Study","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"","keywords":"Medicine; Prothrombin complex concentrate; Randomized controlled trial; Adverse effect; Surgery; Internal medicine; Warfarin; Atrial fibrillation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004371678,0.002364982,0.003306278,0.0003394453,0.0006771655,0.001570289,0.001073634,0.002205597,0.006143909],"category_scores_gemma":[0.002609984,0.0008812501,0.002324087,0.0003819158,0.00166155,0.0013083,0.000485132,0.003164372,0.0013638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007610343,"about_ca_system_score_gemma":0.002390847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005880469,"about_ca_topic_score_gemma":0.001237007,"domain_scores_codex":[0.9987707,0.0006830433,0.00007671193,0.0002118488,0.0000983496,0.0001594546],"domain_scores_gemma":[0.9984323,0.0003899555,0.0003384664,0.000181937,0.0001526801,0.0005045182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9733509,0.01270762,0.0009833818,0.000448805,0.00082216,0.0000580987,0.00007345815,0.0001832777,0.002884739,0.0001180125,0.00118337,0.007186065],"study_design_scores_gemma":[0.9412723,0.05651485,0.001060005,0.00001626213,0.000236888,0.00002759971,0.00001285403,0.0001577393,0.000189056,0.00009826542,0.0004017084,0.00001252305],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790806,0.003126561,0.001085037,0.001160328,0.0008047262,0.01053523,0.001747632,0.0001592635,0.002300632],"genre_scores_gemma":[0.970848,0.002393722,0.003122171,0.002953797,0.0008922711,0.01414303,0.002405183,0.00004885362,0.003193005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006143909,"threshold_uncertainty_score":0.02311987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.115945875750532,"score_gpt":0.3543897788199697,"score_spread":0.2384439030694377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}