{"id":"W3211753107","doi":"10.1182/blood-2021-147377","title":"Dabrafenib, Alone or in Combination with Trametinib, in Pediatric Patients with <i>BRAF</i> V600 Mutation-Positive Langerhans Cell Histiocytosis","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Dabrafenib; Trametinib; Medicine; Internal medicine; Oncology; Rash; MEK inhibitor; Adverse effect; Gastroenterology; Surgery; Vemurafenib; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001276976,0.0004299367,0.001005385,0.0004536218,0.0001653142,0.0006812636,0.0002147591,0.0002610452,0.0009989614],"category_scores_gemma":[0.001526593,0.0002078343,0.001244432,0.001041517,0.0001989832,0.000282182,0.0002330409,0.0004152032,0.0001118711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005786803,"about_ca_system_score_gemma":0.000777685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001506928,"about_ca_topic_score_gemma":0.004277291,"domain_scores_codex":[0.9992994,0.0003142817,0.00009491675,0.0001295273,0.0001034832,0.0000582541],"domain_scores_gemma":[0.9991074,0.0002289142,0.0004502554,0.00003858295,0.00007653637,0.00009822864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.03550391,0.0003870446,0.8111525,0.00152272,0.01364364,0.0009404027,0.000191054,0.001332789,0.007632741,0.0001061281,0.002443244,0.1251438],"study_design_scores_gemma":[0.00620131,0.01839761,0.9356947,0.0004025351,0.01629752,0.00618772,0.0003452882,0.001474012,0.004947679,0.0001244911,0.00989556,0.00003147468],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771616,0.02028163,0.0003641303,0.0001652813,0.00002150895,0.00008066292,0.001090901,0.00001925775,0.0008149806],"genre_scores_gemma":[0.9950591,0.003566826,0.0003251407,0.00009321603,0.00002491185,0.00003597011,0.0007945696,0.000005076555,0.00009529044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001506928,"threshold_uncertainty_score":0.006753325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005219649416107726,"score_gpt":0.2055850398381201,"score_spread":0.2003653904220124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}