{"id":"W3211785283","doi":"10.1002/cam4.4378","title":"Janus kinases restrain chronic lymphocytic leukemia cells in patients on ibrutinib: Results of a phase II trial","year":2021,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research","keywords":"Ruxolitinib; Ibrutinib; Medicine; Janus kinase; Internal medicine; Concomitant; Chronic lymphocytic leukemia; Pharmacology; Leukemia; Cancer research; Immunology; Oncology; Bone marrow; Cytokine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007991501,0.0003676231,0.001215454,0.000389924,0.00007701196,0.00000752453,0.0002598788,0.0002395087,0.0007303578],"category_scores_gemma":[0.002522721,0.0002980938,0.0001538001,0.001125825,0.0005180806,0.00006820806,0.0001492686,0.0004802402,0.00002696667],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.08355048,"about_ca_system_score_gemma":0.06115955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004370961,"about_ca_topic_score_gemma":0.0003971759,"domain_scores_codex":[0.9954219,0.0002150365,0.001338229,0.000822877,0.001421992,0.0007799387],"domain_scores_gemma":[0.9971448,0.0006395644,0.000342696,0.00105603,0.0004007165,0.0004161604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6386084,0.005454135,0.0003415854,0.00396915,0.0008625268,0.00697039,0.006502697,0.002490647,0.06826544,0.0002783118,0.1177032,0.1485535],"study_design_scores_gemma":[0.8750123,0.02093047,0.0006805452,0.004546124,0.0002191178,0.00003067309,0.0001902277,0.003748413,0.0811182,0.00003416145,0.01320807,0.0002817405],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885536,0.002638906,0.000003199457,0.0008284086,0.001151304,0.001337779,0.0001491815,0.0000492611,0.005288294],"genre_scores_gemma":[0.9934401,0.001008406,0.00003246941,0.0006191514,0.001447771,0.0001257239,0.0002667509,0.00005864721,0.003000996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2364039,"threshold_uncertainty_score":0.9999471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0381862828364274,"score_gpt":0.3618438891079292,"score_spread":0.3236576062715018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}