{"id":"W3211785283","doi":"10.1002/cam4.4378","title":"Janus kinases restrain chronic lymphocytic leukemia cells in patients on ibrutinib: Results of a phase II trial","year":2021,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research","keywords":"Ruxolitinib; Ibrutinib; Medicine; Janus kinase; Internal medicine; Concomitant; Chronic lymphocytic leukemia; Pharmacology; Leukemia; Cancer research; Immunology; Oncology; Bone marrow; Cytokine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001340503,0.0009717905,0.00143516,0.0002487554,0.0004121509,0.0008912087,0.0004368627,0.001063676,0.00167509],"category_scores_gemma":[0.0008110165,0.0002990476,0.00107943,0.0002712237,0.0005405394,0.000564325,0.0002447636,0.002437348,0.0004593344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007790119,"about_ca_system_score_gemma":0.0007249353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006403027,"about_ca_topic_score_gemma":0.001791585,"domain_scores_codex":[0.9995914,0.0001528785,0.00003125051,0.00005775972,0.0000379956,0.0001287811],"domain_scores_gemma":[0.9993604,0.0001311132,0.00008275574,0.00004431966,0.00003962719,0.000341782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6120743,0.04330691,0.02226282,0.0007819709,0.001365533,0.0005618032,0.0006148183,0.001649194,0.0872231,0.0003352913,0.004850225,0.2249741],"study_design_scores_gemma":[0.5536647,0.3974436,0.03471213,0.00007716045,0.000716266,0.0005625772,0.000127476,0.001089202,0.005036198,0.0002871135,0.006243744,0.00003996622],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930936,0.003290164,0.0002075263,0.0007315321,0.0001121573,0.0005649978,0.0004459582,0.00005363533,0.00150047],"genre_scores_gemma":[0.9944226,0.001492387,0.0004341628,0.0008224157,0.0001606035,0.0006126833,0.001038247,0.00001396506,0.001002937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00167509,"threshold_uncertainty_score":0.007089376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0381862828364274,"score_gpt":0.3618438891079292,"score_spread":0.3236576062715018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}