{"id":"W3211790423","doi":"10.1182/blood-2021-144905","title":"Olutasidenib (FT-2102) in Combination with Azacitidine Induces Durable Complete Remissions in Patients with mIDH1 Acute Myeloid Leukemia","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Myeloid leukemia; Azacitidine; Gastroenterology; Hypomethylating agent; Refractory (planetary science); Myeloid; Venetoclax; Leukemia; Acute leukemia; Oncology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003430957,0.0003420242,0.001024086,0.0002277278,0.0002719414,0.0004028612,0.0002618873,0.000284333,0.001672418],"category_scores_gemma":[0.0003045538,0.0001631484,0.000342569,0.0002367027,0.0002401365,0.0002252481,0.0002178818,0.001040839,0.0003595172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004148333,"about_ca_system_score_gemma":0.0004884674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006265843,"about_ca_topic_score_gemma":0.00215685,"domain_scores_codex":[0.9998765,0.00003989686,0.0000113325,0.0000207273,0.00001573186,0.00003582038],"domain_scores_gemma":[0.999817,0.00003110419,0.00002978428,0.00001492344,0.00000793086,0.00009931777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2279567,0.02546548,0.03852224,0.0007938117,0.001133204,0.00143949,0.0005595215,0.003585778,0.3440618,0.0003093424,0.005898568,0.3502741],"study_design_scores_gemma":[0.12008,0.5615083,0.2152649,0.0001110297,0.001447334,0.005125315,0.0002923482,0.005226462,0.07272427,0.0004305058,0.01772315,0.00006632583],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972523,0.001070146,0.0002275614,0.00009750634,0.00002300802,0.0001424541,0.0002411828,0.00004674869,0.0008991401],"genre_scores_gemma":[0.9977515,0.0004766117,0.0004214622,0.0001329736,0.00003906475,0.00008850781,0.000595291,0.000007242404,0.0004873854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001672418,"threshold_uncertainty_score":0.00559479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01604588908220709,"score_gpt":0.2547655137594515,"score_spread":0.2387196246772444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}