{"id":"W3211804290","doi":"10.1016/j.vaccine.2021.10.008","title":"A novel DNA platform designed for vaccine use with high transgene expression and immunogenicity","year":2021,"lang":"en","type":"article","venue":"Vaccine","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; Health Sciences Centre; Centre hospitalier de l'Université Laval; Université Laval; University of Manitoba; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Biology; Transgene; Plasmid; Immunogenicity; DNA vaccination; Molecular biology; Transfection; ELISPOT; Expression vector; Promoter; Gene; Expression cassette; Viral vector; Gene expression; Immune system; Vector (molecular biology); Recombinant DNA; Genetics; T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002230169,0.0006217196,0.0003583808,0.0003249039,0.0002671291,0.0004685857,0.0005116823,0.0008822179,0.00142646],"category_scores_gemma":[0.0002329421,0.0002915379,0.0003196031,0.0002408619,0.0002933843,0.0005462228,0.0004518121,0.0008547181,0.0009484518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004125731,"about_ca_system_score_gemma":0.0005731414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002698214,"about_ca_topic_score_gemma":0.0003542634,"domain_scores_codex":[0.9998394,0.00001780944,0.000008205506,0.00004598982,0.00005186039,0.00003664918],"domain_scores_gemma":[0.9998746,0.00001903753,0.00003586322,0.00001057024,0.00002147114,0.00003842457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004473425,0.0000295831,0.00003793976,0.00004623744,0.000004419138,0.00004968484,0.000009559561,0.000197334,0.9954417,0.0005404568,0.00008657747,0.003511848],"study_design_scores_gemma":[0.00002554877,0.0003629906,0.0002106086,0.000006600982,0.00001591574,0.0002350802,0.000007645737,0.001160043,0.9918172,0.0001662563,0.005980852,0.00001125111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6972196,0.003753159,0.2884789,0.0006734201,0.0006968749,0.0005665166,0.0006884546,0.001310468,0.006612597],"genre_scores_gemma":[0.7872602,0.001697703,0.1946614,0.0003997615,0.00008040087,0.0004783864,0.0009248494,0.0001399025,0.01435739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00142646,"threshold_uncertainty_score":0.004772007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02565763493105578,"score_gpt":0.2748368418652448,"score_spread":0.249179206934189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}