{"id":"W3211833564","doi":"10.1016/j.ymben.2021.11.005","title":"Systematic identification of Ocimum sanctum sesquiterpenoid synthases and (−)-eremophilene overproduction in engineered yeast","year":2021,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ministry of Agriculture","funders":"","keywords":"Ocimum; Biology; Yeast; Metabolic engineering; Natural product; Biochemistry; Gene; Biotechnology; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002052123,0.0001265085,0.0002443084,0.00005814192,0.00001439845,0.00001552892,0.00007048127,0.0000914601,0.000005002595],"category_scores_gemma":[0.0004473361,0.0001290976,0.0000478227,0.0001533165,0.00001459401,0.00000720575,0.00004249802,0.00005343009,0.000001035098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006417653,"about_ca_system_score_gemma":0.00002098014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004086056,"about_ca_topic_score_gemma":0.000002003211,"domain_scores_codex":[0.9991799,0.00002733873,0.0003148764,0.0002527765,0.00008998162,0.0001351273],"domain_scores_gemma":[0.9995722,0.00001546644,0.00007516479,0.0002540358,0.00004701232,0.00003608624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007796449,0.00002870593,0.0001472816,0.002044171,0.00004695527,0.00000369589,0.00002263913,0.0008653927,0.9966516,0.00003941082,0.000006808174,0.0001355354],"study_design_scores_gemma":[0.0001294504,0.000006778719,0.005435676,0.0003817318,0.00004403133,0.0000650915,0.00003949136,0.0009892471,0.992601,0.000002642618,0.0001751467,0.0001297501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897645,0.008626776,0.001255383,0.00002195984,0.0001387988,0.0001038389,0.00004627713,0.00001254108,0.00002988916],"genre_scores_gemma":[0.9987902,0.0005418895,0.0003420811,0.000007074401,0.0001248433,0.00001617614,0.00006998291,0.00001300604,0.00009475397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009025657,"threshold_uncertainty_score":0.5264449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003612368732684148,"score_gpt":0.1874161797600186,"score_spread":0.1838038110273345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}