{"id":"W3211838148","doi":"10.1182/blood-2021-146737","title":"High-Dose Methotrexate Is Not Associated with Reduction in CNS Relapse in Patients with Aggressive B-Cell Lymphoma: An International Retrospective Study of 2300 High-Risk Patients","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CNS Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of Calgary; Spinal Cord Injury BC; University of British Columbia","funders":"","keywords":"Medicine; Methotrexate; Retrospective cohort study; Lymphoma; Internal medicine; Oncology; Reduction (mathematics); Rituximab; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001361688,0.0002527435,0.0005440125,0.000256965,0.00004804691,0.00001927927,0.00008785746,0.00009998601,0.00003855625],"category_scores_gemma":[0.0001949349,0.0001968608,0.00004813461,0.0006137192,0.00004296567,0.0001936615,0.00005539791,0.0001394575,0.0000033143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005971112,"about_ca_system_score_gemma":0.0001442814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0024562,"about_ca_topic_score_gemma":0.001280981,"domain_scores_codex":[0.9977848,0.0002305321,0.0004438113,0.0006039171,0.0007049823,0.0002319793],"domain_scores_gemma":[0.9981995,0.00005164569,0.0006456553,0.0003755955,0.000630881,0.00009675726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001470552,0.09358203,0.8993704,0.000007929312,0.0006585458,0.000314944,0.00269592,0.00002321346,0.00003743924,0.000009095193,0.00001246134,0.001817485],"study_design_scores_gemma":[0.1093667,0.005742448,0.8750654,0.0003069494,0.0005981675,0.000004290489,0.0006394089,0.000007685961,0.008083749,0.00001682247,0.000001060654,0.0001672464],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985656,0.00003040849,4.808909e-7,0.00004331584,0.000155999,0.000893632,0.0002127793,0.00002196146,0.00007580937],"genre_scores_gemma":[0.9988213,0.00004711893,0.0003602793,0.00002920269,0.00002853777,0.0001119137,0.000499864,0.00004009889,0.00006168021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1078962,"threshold_uncertainty_score":0.8027753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007138644328554607,"score_gpt":0.230745298865182,"score_spread":0.2236066545366274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}