{"id":"W3211838148","doi":"10.1182/blood-2021-146737","title":"High-Dose Methotrexate Is Not Associated with Reduction in CNS Relapse in Patients with Aggressive B-Cell Lymphoma: An International Retrospective Study of 2300 High-Risk Patients","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CNS Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of Calgary; Spinal Cord Injury BC; University of British Columbia","funders":"","keywords":"Medicine; Methotrexate; Retrospective cohort study; Lymphoma; Internal medicine; Oncology; Reduction (mathematics); Rituximab; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003697919,0.0001826919,0.0003370318,0.0006332651,0.0003358114,0.0006247891,0.0003057699,0.0003344922,0.001369213],"category_scores_gemma":[0.001542779,0.0002298571,0.000336846,0.001056801,0.0002836093,0.0003508879,0.0003299067,0.0003739608,0.0003150189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003268998,"about_ca_system_score_gemma":0.0003066261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003350223,"about_ca_topic_score_gemma":0.002671176,"domain_scores_codex":[0.9995516,0.000101791,0.00006424396,0.0001608772,0.00007277435,0.00004867626],"domain_scores_gemma":[0.9983562,0.0002392676,0.0008901959,0.0001271966,0.0001422294,0.0002448905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001098608,0.00001999611,0.9990519,0.000007468111,0.00002938153,0.0001316146,0.00003715658,0.000009664315,0.0001097128,0.000004225918,0.00003133813,0.0004577784],"study_design_scores_gemma":[0.00001699344,0.0002340216,0.9980811,0.000006336168,0.00005099361,0.001069529,0.0001372488,0.00007562229,0.00006717915,0.000007820669,0.0002497294,0.000003368173],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992378,0.000282471,0.00003161656,0.00000978864,0.00000223125,0.000006082404,0.0001724351,0.000001717585,0.0002558768],"genre_scores_gemma":[0.9995223,0.0001230563,0.00003349931,0.00001582566,0.000006367649,0.000006996897,0.0002322609,0.000001447956,0.00005836787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003350223,"threshold_uncertainty_score":0.006661475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007138644328554607,"score_gpt":0.230745298865182,"score_spread":0.2236066545366274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}