{"id":"W3211851395","doi":"10.1039/d1sc05021d","title":"Chiral, sequence-definable foldamer-derived macrocycles","year":2021,"lang":"en","type":"article","venue":"Chemical Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Engineering and Physical Sciences Research Council; Queen's University; Queen's University Belfast; University of Southampton; Department for the Economy","keywords":"Foldamer; Trimer; Sequence (biology); Chemistry; Macromolecule; Stereochemistry; Crystallography; Dimer; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001310778,0.00012199,0.0001457727,0.00001765202,0.0001329201,0.00007425385,0.000400359,0.00008476285,0.0001679552],"category_scores_gemma":[0.00041445,0.0001071275,0.0001260991,0.0004352017,0.0005316774,0.000008073537,0.000325273,0.00007468811,0.00003230857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003160709,"about_ca_system_score_gemma":0.0001563422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001231453,"about_ca_topic_score_gemma":0.000002195091,"domain_scores_codex":[0.9986075,0.00001172356,0.0001548859,0.0005857246,0.0002525196,0.0003876823],"domain_scores_gemma":[0.9992667,0.00001265416,0.00004326987,0.0003707595,0.0001195937,0.0001870119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004376995,0.0000406769,0.000297943,0.000005013909,0.000008285365,0.000005303459,0.00000612126,0.000002259244,0.9954258,0.0001241027,0.0004287169,0.003651463],"study_design_scores_gemma":[0.0001018552,0.00000891894,0.0001197255,0.000009353414,0.0000113985,0.00001692862,0.00003266193,0.00006288068,0.9876228,0.0004964123,0.01134971,0.0001673455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917758,0.0004345238,0.0001512907,0.000468589,0.00003607784,0.00002745015,0.000006622061,0.00001602819,0.007083662],"genre_scores_gemma":[0.9966136,0.0001324393,0.001917216,0.000442746,0.0001259621,0.000007629564,0.00002904102,0.000008654525,0.0007226814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01092099,"threshold_uncertainty_score":0.4368531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633319987061613,"score_gpt":0.2673384344470419,"score_spread":0.2510052345764258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}