{"id":"W3211851395","doi":"10.1039/d1sc05021d","title":"Chiral, sequence-definable foldamer-derived macrocycles","year":2021,"lang":"en","type":"article","venue":"Chemical Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Engineering and Physical Sciences Research Council; Queen's University; Queen's University Belfast; University of Southampton; Department for the Economy","keywords":"Foldamer; Trimer; Sequence (biology); Chemistry; Macromolecule; Stereochemistry; Crystallography; Dimer; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008729206,0.0002656243,0.0002132008,0.0001458171,0.000136776,0.0002908314,0.0001841226,0.0002415007,0.002449154],"category_scores_gemma":[0.0001862108,0.0001031659,0.00008510813,0.0001148924,0.0001650431,0.0001663091,0.0001819314,0.0004115165,0.0007118359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002218426,"about_ca_system_score_gemma":0.0001858095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002009337,"about_ca_topic_score_gemma":0.0006053273,"domain_scores_codex":[0.9999408,0.000007688845,0.000005054601,0.00001873083,0.00001137399,0.00001646333],"domain_scores_gemma":[0.9999387,0.000006906672,0.00001685249,0.00001023448,0.000009610195,0.00001764069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000096463,0.00004232732,0.00009211097,0.00008867362,0.000004937716,0.0001189,0.00003324915,0.0009369589,0.9814501,0.005019444,0.0006405206,0.01147638],"study_design_scores_gemma":[0.00002917844,0.0004360985,0.0006452843,0.00001166231,0.000007780704,0.0001863075,0.00001965385,0.00252991,0.9747924,0.0005026435,0.02081686,0.00002234122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9373863,0.001929243,0.0322527,0.0003335693,0.0003710971,0.0003083232,0.001000212,0.001138971,0.02527951],"genre_scores_gemma":[0.9626873,0.0009507862,0.02624147,0.0002333186,0.00004583061,0.0002767402,0.0004830815,0.0001049076,0.008976461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002449154,"threshold_uncertainty_score":0.008193254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633319987061613,"score_gpt":0.2673384344470419,"score_spread":0.2510052345764258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}