{"id":"W3211908582","doi":"10.1016/j.bmc.2021.116501","title":"Synthetic development of sugar amino acid oligomers towards novel podophyllotoxin analogues","year":2021,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Saint-François d'Assise; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Université Laval","keywords":"Chemistry; Podophyllotoxin; Solubility; Sugar; Amino acid; Organic chemistry; Lipophilicity; Glucosamine; Chemical synthesis; Amino sugar; Combinatorial chemistry; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382939,0.0003030739,0.0001430404,0.0001526721,0.0001340583,0.0002480373,0.0001967216,0.0002178414,0.00125165],"category_scores_gemma":[0.0001495394,0.0001042873,0.0001923516,0.0002099954,0.0001195917,0.0003164631,0.0002371706,0.0005178731,0.000400554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001931664,"about_ca_system_score_gemma":0.000256774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002027318,"about_ca_topic_score_gemma":0.00053183,"domain_scores_codex":[0.9999431,0.00001070778,0.000005753752,0.000009845401,0.000008729025,0.00002187185],"domain_scores_gemma":[0.9999328,0.000008455373,0.00001928604,0.000007122093,0.00001039748,0.00002194946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001147872,0.0001275828,0.000158341,0.0001365016,0.0000122632,0.0003047342,0.00008421668,0.001526494,0.9851565,0.002351333,0.000116409,0.009910814],"study_design_scores_gemma":[0.00004721598,0.001071775,0.0007410569,0.00002458257,0.00002734588,0.0002205957,0.00006481075,0.001592171,0.9869962,0.0004928248,0.008706842,0.00001461503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9640038,0.001836021,0.02281007,0.0001802513,0.0001103294,0.0001531174,0.0002755796,0.00008601421,0.0105448],"genre_scores_gemma":[0.9856947,0.00197113,0.008691385,0.00006070661,0.00001334316,0.00004594479,0.0002593825,0.00001556107,0.003247789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00125165,"threshold_uncertainty_score":0.004187167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01693866091305347,"score_gpt":0.2305483660335199,"score_spread":0.2136097051204665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}