{"id":"W3211908582","doi":"10.1016/j.bmc.2021.116501","title":"Synthetic development of sugar amino acid oligomers towards novel podophyllotoxin analogues","year":2021,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Saint-François d'Assise; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Université Laval","keywords":"Chemistry; Podophyllotoxin; Solubility; Sugar; Amino acid; Organic chemistry; Lipophilicity; Glucosamine; Chemical synthesis; Amino sugar; Combinatorial chemistry; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002699329,0.0002917179,0.0003850099,0.00002692599,0.0000856889,0.00001304485,0.0003165774,0.0002858066,0.0002100382],"category_scores_gemma":[0.0002349195,0.000262647,0.0001353577,0.0001762624,0.0001982042,0.000004485054,0.0001853595,0.0001473893,0.00000925195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005672133,"about_ca_system_score_gemma":0.0008170556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001458671,"about_ca_topic_score_gemma":0.00001474691,"domain_scores_codex":[0.9982351,0.00003335462,0.0004277496,0.000568841,0.0003625459,0.0003724185],"domain_scores_gemma":[0.9989665,0.00001988185,0.0001869665,0.0004863554,0.0001499364,0.000190327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005167065,0.0002342929,0.0003704716,0.0001654323,0.0001611594,0.00002248743,0.00009120372,1.909329e-7,0.9938415,0.000002754441,0.0001780726,0.004880784],"study_design_scores_gemma":[0.0004318302,0.00004881803,0.004056,0.0001110327,0.00006158748,0.0001760307,0.0005288515,0.000003295107,0.9860089,0.000003148887,0.008273793,0.000296644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947866,0.00170704,0.001206409,0.0001671625,0.000121007,0.00007453835,0.0000998144,0.00001982194,0.001817623],"genre_scores_gemma":[0.9963239,0.0001824255,0.002413051,0.0001122701,0.0002474961,0.000008972021,0.0002999567,0.00002959947,0.000382365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008095721,"threshold_uncertainty_score":0.9999826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01693866091305347,"score_gpt":0.2305483660335199,"score_spread":0.2136097051204665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}