{"id":"W3211914517","doi":"10.1182/blood-2021-146012","title":"Rapid and Sustained Reduction of Immunosuppressive T-Cells and Focusing of the T-Cell Repertoire in t(11;14) Relapsed/Refractory Multiple Myeloma Patients Treated with Venetoclax in Combination with Daratumumab and Dexamethasone","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Daratumumab; Venetoclax; Multiple myeloma; Medicine; Refractory (planetary science); Lenalidomide; Immunology; Cancer research; Oncology; Biology; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001909584,0.0001789788,0.0004496162,0.0001754214,0.0001617912,0.0002865742,0.0001228963,0.0001226615,0.0008382382],"category_scores_gemma":[0.0002198733,0.00008967566,0.000148028,0.000138362,0.0001058695,0.00008762892,0.0001192971,0.0004596653,0.0001432056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001641128,"about_ca_system_score_gemma":0.0001827274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002847044,"about_ca_topic_score_gemma":0.0006868332,"domain_scores_codex":[0.9998978,0.00002123734,0.000008989454,0.00002374936,0.00002013714,0.00002805359],"domain_scores_gemma":[0.9999125,0.00001477383,0.00002158403,0.000008931707,0.000007703572,0.00003450852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.02123644,0.001851891,0.03899021,0.0002362189,0.0001702573,0.0008773676,0.0002902431,0.001044711,0.798651,0.0001016448,0.001375072,0.1351751],"study_design_scores_gemma":[0.006354055,0.1178026,0.5184818,0.00009101034,0.0006675671,0.009695265,0.00041361,0.006579787,0.3200253,0.0002356364,0.01959829,0.0000550332],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987206,0.0006166831,0.0001248414,0.00002085891,0.00001039866,0.00002340065,0.00007798275,0.00001784703,0.0003873534],"genre_scores_gemma":[0.9991691,0.000121585,0.0002499198,0.0000302466,0.000008123615,0.00001765533,0.0001415859,0.000002460576,0.0002593278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008382382,"threshold_uncertainty_score":0.00280422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008048729171041265,"score_gpt":0.2196971698775891,"score_spread":0.2116484407065479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}