{"id":"W3211916276","doi":"10.1128/spectrum.00886-21","title":"Evaluating Humoral Immunity against SARS-CoV-2: Validation of a Plaque-Reduction Neutralization Test and a Multilaboratory Comparison of Conventional and Surrogate Neutralization Assays","year":2021,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Public Health Agency of Canada; McGill University; BC Centre for Disease Control; Sunnybrook Health Science Centre; Sinai Health System; University of Toronto; Université de Montréal; University of Alberta; Health Sciences Centre; Mount Sinai Hospital; University of Manitoba","funders":"Canadian Institutes of Health Research; Fondation du CHUM; Canada Foundation for Innovation; Ministère de l'Économie, de la Science et de l'Innovation - Québec; Public Health Agency of Canada; Government of Canada","keywords":"Neutralization; Humoral immunity; Immunity; Antibody; Immune system; Serology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01226198,0.001616877,0.0006543857,0.00120147,0.000522074,0.0009018535,0.00127397,0.001317815,0.0008343235],"category_scores_gemma":[0.007919787,0.0004615029,0.0006222121,0.0007165768,0.001164687,0.0007441906,0.001056698,0.001495917,0.0004367672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005412597,"about_ca_system_score_gemma":0.0006343098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001142015,"about_ca_topic_score_gemma":0.001119765,"domain_scores_codex":[0.9812471,0.009508989,0.001036352,0.001964925,0.005726397,0.0005160834],"domain_scores_gemma":[0.9955724,0.00146274,0.0005373756,0.0006850763,0.001539961,0.0002023703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001082034,0.001550131,0.01067948,0.0003681682,0.0001233336,0.0000688642,0.0004191931,0.001270819,0.9638023,0.0007875617,0.0003059812,0.01954211],"study_design_scores_gemma":[0.0002048908,0.01467004,0.03434123,0.0001012239,0.0001794857,0.0009599802,0.0002066284,0.01255224,0.9309867,0.0005163136,0.005178534,0.0001027075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8394039,0.002127962,0.1501815,0.000232689,0.0004010155,0.002042753,0.0009534303,0.0003394751,0.004317163],"genre_scores_gemma":[0.8559315,0.001037043,0.1369942,0.0002804623,0.000122244,0.001264125,0.001943942,0.00005988016,0.002366611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01226198,"threshold_uncertainty_score":0.06484836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07318208725475162,"score_gpt":0.3916027410985952,"score_spread":0.3184206538438436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}