{"id":"W3211916276","doi":"10.1128/spectrum.00886-21","title":"Evaluating Humoral Immunity against SARS-CoV-2: Validation of a Plaque-Reduction Neutralization Test and a Multilaboratory Comparison of Conventional and Surrogate Neutralization Assays","year":2021,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Public Health Agency of Canada; McGill University; BC Centre for Disease Control; Sunnybrook Health Science Centre; Sinai Health System; University of Toronto; Université de Montréal; University of Alberta; Health Sciences Centre; Mount Sinai Hospital; University of Manitoba","funders":"Canadian Institutes of Health Research; Fondation du CHUM; Canada Foundation for Innovation; Ministère de l'Économie, de la Science et de l'Innovation - Québec; Public Health Agency of Canada; Government of Canada","keywords":"Neutralization; Humoral immunity; Immunity; Antibody; Immune system; Serology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005662998,0.0001656329,0.0004391118,0.0002149998,0.0001149856,0.00001941715,0.00005908537,0.0001918234,0.000009623999],"category_scores_gemma":[0.000259777,0.0001729057,0.00006020351,0.0004189474,0.0003469649,0.0001253498,0.00007298368,0.0002298733,0.00000277164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007942956,"about_ca_system_score_gemma":0.0002668572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001340424,"about_ca_topic_score_gemma":0.00009548131,"domain_scores_codex":[0.9984158,0.0003468511,0.0005502722,0.0003379667,0.000122879,0.0002262702],"domain_scores_gemma":[0.9988744,0.0001426508,0.0003137889,0.0002057947,0.0004429767,0.00002033579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001608578,0.0003173166,0.1648816,0.0002131643,0.00005882405,0.000003479947,0.0003973158,0.00001346151,0.8334404,0.0002262575,0.00005071949,0.0002365737],"study_design_scores_gemma":[0.002156479,0.0004462085,0.03250053,0.0001259578,0.00008764106,0.00009624274,0.0003279025,0.002460804,0.9612918,0.000101931,0.0002822335,0.0001222744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981688,0.0006289494,0.0002748246,0.0002717568,0.0001247224,0.0003606048,0.00006756074,0.0000307536,0.00007202203],"genre_scores_gemma":[0.9984215,0.0000274019,0.0005139536,0.0004822226,0.00004664291,0.00001119347,0.0004729985,0.00001799952,0.000006075458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1323811,"threshold_uncertainty_score":0.705089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07318208725475162,"score_gpt":0.3916027410985952,"score_spread":0.3184206538438436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}