{"id":"W3211920496","doi":"10.1016/s2152-2650(21)02092-9","title":"OAB-018: A BCL2L1 armoured BCMA-targeting CAR T cells to overcome exhaustion and enhance persistence in multiple myeloma","year":2021,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Chimeric antigen receptor; CD28; TIGIT; T cell; CAR T-cell therapy; CD19; Cancer research; Biology; Immunology; Cell biology; Antigen; Medicine; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003335652,0.0003115993,0.0004250483,0.0004025109,0.0003618142,0.001000953,0.0006419041,0.0005145494,0.002854194],"category_scores_gemma":[0.0002024404,0.0001999441,0.0002582348,0.0004746092,0.0003374714,0.0004918986,0.0003769597,0.00192312,0.0006827169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008694615,"about_ca_system_score_gemma":0.0007116334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001512489,"about_ca_topic_score_gemma":0.002570287,"domain_scores_codex":[0.9997694,0.00003021603,0.0000129808,0.00003083613,0.00004338823,0.0001131778],"domain_scores_gemma":[0.9999241,0.00001028644,0.00001016957,0.00001023585,0.00001014487,0.00003520361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003863184,0.002100567,0.001524474,0.0003482451,0.0001089516,0.0002082469,0.0001821545,0.002383607,0.8939233,0.002457127,0.004392784,0.08850745],"study_design_scores_gemma":[0.003356356,0.0161794,0.01081336,0.00006025251,0.0003196394,0.00158538,0.0002148489,0.01091855,0.8902097,0.0008092956,0.06546549,0.00006766378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880639,0.00417053,0.002112449,0.0007382946,0.0001687143,0.0001061379,0.0003910171,0.0003314724,0.003917577],"genre_scores_gemma":[0.9946332,0.0008503913,0.001000729,0.0001326549,0.00002383029,0.00007322028,0.0004718271,0.00002978778,0.002784368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002854194,"threshold_uncertainty_score":0.009548247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05083502320690806,"score_gpt":0.3430883051662408,"score_spread":0.2922532819593328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}