{"id":"W3211931509","doi":"10.1182/blood-2021-147551","title":"Disrupting Ectopic Super-Enhancers to Treat Multiple Myeloma","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Enhancer; BRD4; Bromodomain; Cancer research; Bortezomib; Biology; Ixazomib; Transcription factor; Multiple myeloma; Chromatin; Acetylation; Carfilzomib; Genetics; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001587188,0.0002539202,0.0002694527,0.0002684488,0.0001373032,0.0002681171,0.0003092725,0.0003037552,0.001882149],"category_scores_gemma":[0.00009005624,0.0001157879,0.0003125318,0.0002329414,0.0002473411,0.0002030394,0.0002628498,0.001239885,0.0005242095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003005688,"about_ca_system_score_gemma":0.000197781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004208686,"about_ca_topic_score_gemma":0.0005955711,"domain_scores_codex":[0.9998555,0.00001555832,0.00001091819,0.00003413357,0.00005559739,0.00002827126],"domain_scores_gemma":[0.9999253,0.00001258755,0.00002095081,0.00001320424,0.000009785935,0.00001821958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001217355,0.00008738516,0.000146498,0.0001181609,0.00001502706,0.00007489219,0.00001950247,0.0003071555,0.9906969,0.0005332617,0.000349383,0.007530128],"study_design_scores_gemma":[0.0000561671,0.0006135732,0.00113019,0.00001343661,0.00003837514,0.0003823652,0.00002118399,0.0014491,0.9753026,0.0002097822,0.02077467,0.000008532442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9119622,0.0284201,0.0437722,0.001402418,0.0006978422,0.0002350459,0.001550917,0.001581261,0.01037813],"genre_scores_gemma":[0.9796292,0.005387271,0.008966985,0.000281411,0.00004754661,0.00008459431,0.0007415435,0.00007744516,0.0047839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001882149,"threshold_uncertainty_score":0.006296396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0265716416777689,"score_gpt":0.3091943180502529,"score_spread":0.2826226763724841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}