{"id":"W3211944402","doi":"10.1038/s41388-021-02107-7","title":"Emergence of β1 integrin-deficient breast tumours from dormancy involves both inactivation of p53 and generation of a permissive tumour microenvironment","year":2021,"lang":"en","type":"article","venue":"Oncogene","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; McGill University","keywords":"Biology; Integrin; Cancer research; Dormancy; Extracellular matrix; Stromal cell; Anoikis; Cell biology; Cancer cell; Cancer; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008161982,0.0001002562,0.0003059722,0.00006243066,0.00001905597,0.000002553521,0.00003432466,0.00003696918,0.000354402],"category_scores_gemma":[0.00002156721,0.00008962031,0.00006995468,0.0001383911,0.00006791052,0.00004215743,0.00004652965,0.00005750129,8.482485e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004151749,"about_ca_system_score_gemma":0.0001354147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004865297,"about_ca_topic_score_gemma":0.00008885645,"domain_scores_codex":[0.9991146,0.00003225097,0.0003425776,0.000201678,0.0002168499,0.00009203733],"domain_scores_gemma":[0.9993796,0.00001546638,0.0002483455,0.0001784732,0.0001146278,0.00006347543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000856398,0.0002752783,0.008481332,0.0001219197,0.00005273642,0.000006348218,0.000841379,0.00003314822,0.9757115,0.00002386616,0.0001815916,0.0141853],"study_design_scores_gemma":[0.000685533,0.0001543612,0.04466087,0.0001789159,0.0001578298,0.00002562025,0.001772916,0.0001475419,0.9518889,0.00001175701,0.0002490493,0.00006668957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935396,0.00510835,0.0005552653,0.0002041843,0.00009416988,0.0001369111,0.0001598581,0.000002991985,0.000198722],"genre_scores_gemma":[0.9945364,0.002503737,0.002618503,0.00003739675,0.00007517474,0.000006272358,0.0001157666,0.00001067063,0.00009609012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03617954,"threshold_uncertainty_score":0.3880453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02729597252828414,"score_gpt":0.260065221255351,"score_spread":0.2327692487270669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}