{"id":"W3211989459","doi":"10.1038/s41467-021-26847-y","title":"Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"CIHR Skin Research Training Centre; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Health and Human Services; Government of Canada; National Institutes of Health; Canadian Institutes of Health Research; Alberta Innovates","keywords":"Vibrio cholerae; Pandemic; El Tor; Cholera; Type VI secretion system; Biology; Microbiology; Cholera toxin; Virology; Bacteria; Coronavirus disease 2019 (COVID-19); Virulence; Genetics; Gene; Infectious disease (medical specialty); Disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395728,0.0002238138,0.0002351959,0.0001434544,0.00009615879,0.0002470736,0.0002973509,0.0003748669,0.002482768],"category_scores_gemma":[0.0003716722,0.0001411425,0.0002473034,0.000118869,0.0002057224,0.0001249526,0.0002079346,0.0005132447,0.0002491304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002154632,"about_ca_system_score_gemma":0.0002399667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001569901,"about_ca_topic_score_gemma":0.00204655,"domain_scores_codex":[0.9997365,0.00004223722,0.00002535856,0.0000451599,0.00006748098,0.00008323338],"domain_scores_gemma":[0.9997469,0.00005408206,0.00005012269,0.00003720769,0.00003865605,0.00007310286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003515706,0.0001068597,0.00120994,0.00002673698,0.00001742163,0.00009706787,0.00004023637,0.00008930507,0.9965383,0.00007096363,0.00008411146,0.001367443],"study_design_scores_gemma":[0.00006449164,0.003453551,0.1005438,0.00002207373,0.00005042175,0.00112097,0.0002692302,0.001845644,0.8894103,0.0001716249,0.003017622,0.00003039549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999258,0.00007938413,0.0001305384,0.0000190731,0.00001461154,0.000005135863,0.0001202523,0.000007164911,0.0003658364],"genre_scores_gemma":[0.9979913,0.00006108882,0.0002955112,0.00004073275,0.000003626622,0.000006734966,0.000239954,0.00001502712,0.001346033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002482768,"threshold_uncertainty_score":0.008305728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02089437237206205,"score_gpt":0.3254461201658583,"score_spread":0.3045517477937962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}