{"id":"W3212048545","doi":"10.1016/j.nbd.2021.105557","title":"Neuropathological evidence of body-first vs. brain-first Lewy body disease","year":2021,"lang":"en","type":"review","venue":"Neurobiology of Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":211,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Lundbeckfonden; Weston Brain Institute; Academy of Finland; Parkinson's UK; Michael J. Fox Foundation for Parkinson's Research","keywords":"Lewy body; Brainstem; Alpha-synuclein; Neuroscience; Neuropathology; Amygdala; Pathology; Substantia nigra; Entorhinal cortex; Parkinson's disease; Dementia with Lewy bodies; Central nervous system; Medicine; Psychology; Dementia; Disease; Hippocampus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002328931,0.001005573,0.00387131,0.0003610063,0.0001511295,0.00001785117,0.000599602,0.0003881234,0.0004728161],"category_scores_gemma":[0.002478077,0.0007758951,0.002229145,0.0005154037,0.0006439304,0.00009579314,0.0005100769,0.0005603018,0.0001045556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000928642,"about_ca_system_score_gemma":0.001413491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009578807,"about_ca_topic_score_gemma":0.000001672027,"domain_scores_codex":[0.9949915,0.0008568647,0.001345052,0.001669363,0.0004405527,0.0006966607],"domain_scores_gemma":[0.9943482,0.001102543,0.0009589586,0.001793926,0.0002532793,0.001543154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02164782,0.04545587,0.07314077,0.587268,0.007256901,0.05069336,0.0001273159,0.00002867566,0.0003585825,0.005696397,0.03152667,0.1767997],"study_design_scores_gemma":[0.002066846,0.002224086,0.04518155,0.03925898,0.0154563,0.00008506288,0.000003961944,0.000007882847,0.00003053085,0.00007440846,0.894779,0.0008313584],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01022487,0.9849133,0.00001255582,0.00106323,0.0006037783,0.001769421,0.001224764,0.0001064324,0.00008157271],"genre_scores_gemma":[0.05043873,0.9469272,0.00005147056,0.0008327886,0.0002042359,0.0002820701,0.0008554789,0.0001226844,0.0002852885],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8632523,"threshold_uncertainty_score":0.9994692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05781917569674645,"score_gpt":0.3421988932578492,"score_spread":0.2843797175611028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}