{"id":"W3212053684","doi":"10.1111/imm.13427","title":"NLRP3 knockout enhances immune infiltration and inflammatory responses and improves survival in a burn sepsis model","year":2021,"lang":"en","type":"article","venue":"Immunology","topic":"Burn Injury Management and Outcomes","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto; Sunnybrook Hospital","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Canada Foundation for Innovation; Foundation for the National Institutes of Health","keywords":"Sepsis; Inflammation; Medicine; Infiltration (HVAC); Inflammasome; Burn injury; Immune system; Immunology; Pathophysiology; Tumor necrosis factor alpha; Internal medicine; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002264354,0.0001276602,0.000313412,0.000173024,0.00005497831,0.00002642906,0.00004514024,0.0001212187,0.00003160767],"category_scores_gemma":[0.0002028732,0.0001184575,0.00003315871,0.0001211266,0.0001495542,0.0001533113,0.0001212294,0.0001811596,0.000005439152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002393955,"about_ca_system_score_gemma":0.00008164451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004556255,"about_ca_topic_score_gemma":0.0001187436,"domain_scores_codex":[0.999106,0.00009899783,0.000284163,0.0002332212,0.00007890795,0.0001987408],"domain_scores_gemma":[0.9995109,0.000134236,0.00006474447,0.0002101788,0.00005266609,0.00002725058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009869853,0.00007350861,0.055289,0.0001355982,0.0001913888,0.000101624,0.001355692,0.000004071152,0.9185439,0.004277641,0.00003753627,0.01900306],"study_design_scores_gemma":[0.002567675,0.0002520861,0.9271222,0.00009044034,0.00007437525,0.0000639709,0.001504929,0.001043057,0.06349958,0.001713398,0.001850744,0.0002174981],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890352,0.007241852,0.00007921852,0.001735215,0.0001799093,0.0001591055,0.000002115135,0.00003797437,0.00152937],"genre_scores_gemma":[0.9935182,0.002217116,0.0003936272,0.0002041283,0.00003364236,0.00002010953,0.00001314951,0.00001189456,0.00358816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8718333,"threshold_uncertainty_score":0.4830556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01691789360099452,"score_gpt":0.2821564995871502,"score_spread":0.2652386059861557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}