{"id":"W3212061784","doi":"10.1371/journal.pone.0259197","title":"A B-cell developmental gene regulatory network is activated in infant AML","year":2021,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"BC Cancer Agency; Children’s Oncology Group; Rally Foundation; National Cancer Institute; National Institutes of Health; Pride Foundation","keywords":"Epigenetics; Biology; Myeloid leukemia; DNA methylation; Epigenomics; Gene; Cancer research; Bioinformatics; Genetics; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000713712,0.0000940809,0.0001121947,0.00002206993,0.00003717886,0.00001326544,0.00007413371,0.0001100842,0.0001299528],"category_scores_gemma":[0.0000359291,0.0001029959,0.00003130718,0.0001459976,0.00002132171,0.000003613952,0.0001007759,0.00007933559,0.00002596003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002563478,"about_ca_system_score_gemma":0.0001399455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005415363,"about_ca_topic_score_gemma":0.00001639065,"domain_scores_codex":[0.9992393,0.00003912283,0.0001613208,0.0002456463,0.0001330258,0.000181626],"domain_scores_gemma":[0.9996648,0.000003560945,0.00004283958,0.0001802645,0.00005481963,0.00005367918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002645981,0.0003641216,0.004138961,0.00001116816,0.00004368684,0.000007003955,0.00003253115,0.000002942784,0.991445,0.000005922623,0.003694814,0.0002273872],"study_design_scores_gemma":[0.0004998002,0.00003300456,0.004178638,0.0000436466,0.000007564721,0.000002814652,0.00002352339,0.00001896473,0.9912609,0.00001878671,0.003772727,0.0001395659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968601,0.0007119139,0.00002836,0.0001549584,0.00003214888,0.0001175807,0.000006380174,0.00001106733,0.002077455],"genre_scores_gemma":[0.9888263,0.000179057,0.007057676,0.0008872043,0.0001677723,0.00002506332,0.000190933,0.00001639137,0.002649657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008033889,"threshold_uncertainty_score":0.4200051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01708146323197414,"score_gpt":0.1998978215245787,"score_spread":0.1828163582926046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}