{"id":"W3212128030","doi":"10.1515/cclm-2021-0651","title":"Validation of the LUMIPULSE automated immunoassay for the measurement of core AD biomarkers in cerebrospinal fluid","year":2021,"lang":"en","type":"article","venue":"Clinical Chemistry and Laboratory Medicine (CCLM)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; McGill University; Douglas Mental Health University Institute; Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; UK Dementia Research Institute; Vetenskapsrådet; Hjärnfonden; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer's Association; Consortium canadien en neurodégénérescence associée au vieillissement; Alzheimer's Drug Discovery Foundation; Canadian Institutes of Health Research; Weston Brain Institute; European Commission; Fondation Brain Canada; Stiftelsen för Gamla Tjänarinnor","keywords":"Immunoassay; Reproducibility; Repeatability; Cerebrospinal fluid; Medicine; Biomarker; Roche Diagnostics; Pathology; Chromatography; Internal medicine; Chemistry; Immunology; Antibody; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001460127,0.0001413642,0.0004298437,0.00001420712,0.00007250429,0.00000390501,0.0001236084,0.0001313767,0.000125907],"category_scores_gemma":[0.00287941,0.00007767965,0.0001213275,0.0003944368,0.0006957865,0.00002869584,0.00005866306,0.0002120267,6.807426e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004959227,"about_ca_system_score_gemma":0.0008123042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001241941,"about_ca_topic_score_gemma":0.000002758517,"domain_scores_codex":[0.9982231,0.0001086587,0.0006949079,0.0002660106,0.0005203116,0.0001869898],"domain_scores_gemma":[0.9978226,0.0004842234,0.0002151792,0.000476506,0.0008291841,0.0001723203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006969826,0.003343655,0.4087866,0.004017314,0.01502645,0.0001319054,0.0003689214,0.000009993242,0.5415332,0.00004341363,0.01478624,0.004982497],"study_design_scores_gemma":[0.01677207,0.0008259338,0.4284272,0.002432047,0.002362205,0.00001964636,0.001650679,0.001401164,0.5438514,0.0001402906,0.001903742,0.0002136026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769154,0.01993641,0.000006956293,0.002129128,0.0001334179,0.0005068153,0.00008904842,0.00002104829,0.0002618019],"genre_scores_gemma":[0.9989308,0.0006364684,0.00004886032,0.000149437,0.00009496218,0.00004009544,0.00006443346,0.00001218106,0.00002283065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02201536,"threshold_uncertainty_score":0.344713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08265931393636057,"score_gpt":0.3888288326540112,"score_spread":0.3061695187176507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}