{"id":"W3212160629","doi":"10.1182/blood-2021-150172","title":"Pelabresib (CPI-0610) Monotherapy in Patients with Myelofibrosis - Update of Clinical and Translational Data from the Ongoing Manifest Trial","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Myelofibrosis; Clinical trial; Internal medicine; Pediatrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003635888,0.0005538403,0.001783091,0.0002974717,0.0002162459,0.001642501,0.0006210787,0.0007181878,0.003543421],"category_scores_gemma":[0.002076751,0.0002383423,0.001093082,0.0005412194,0.0003935255,0.0009647121,0.0004020898,0.002204341,0.000649002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000644738,"about_ca_system_score_gemma":0.0007921458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003465523,"about_ca_topic_score_gemma":0.001562921,"domain_scores_codex":[0.9992959,0.0003213607,0.000092054,0.00007688627,0.0001279543,0.00008571109],"domain_scores_gemma":[0.9980581,0.0006565721,0.0005993587,0.00009891527,0.0002883785,0.0002984989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1650061,0.004258054,0.02256924,0.01315668,0.005281454,0.0005623546,0.0004259789,0.001958447,0.03008075,0.0017672,0.04861936,0.7063144],"study_design_scores_gemma":[0.3153302,0.1771056,0.1879532,0.006843451,0.01474169,0.003387299,0.0006127274,0.00389924,0.008639632,0.002955609,0.2782443,0.0002871478],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5352288,0.414569,0.002107869,0.01089122,0.001399375,0.001507177,0.008997258,0.0004906916,0.02480854],"genre_scores_gemma":[0.8609085,0.1015231,0.003186288,0.01102701,0.001896511,0.001298297,0.01621476,0.00009323227,0.003852321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003635888,"threshold_uncertainty_score":0.01922864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05403096430950102,"score_gpt":0.3240995657734011,"score_spread":0.2700686014639001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}