{"id":"W3212175095","doi":"10.1101/2020.12.18.423106","title":"SARS-CoV-2 spike-glycoprotein processing at S1/S2 and S2’and shedding of the ACE2 viral receptor: roles of Furin and TMPRSS2 and implications for viral infectivity and cell-to-cell fusion","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Furin; Viral entry; Biology; Cell fusion; Lipid bilayer fusion; Cleavage (geology); Viral envelope; Syncytium; Infectivity; Virology; Proteolysis; Molecular biology; Cell biology; Cell; Biochemistry; Virus; Enzyme; Viral replication","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001678226,0.0002580566,0.0002323231,0.00008690129,0.0001297512,0.0003508277,0.0001121603,0.0002217324,0.0007181393],"category_scores_gemma":[0.0001136295,0.0001247309,0.0003237419,0.00008553406,0.0001843035,0.0002406927,0.000119466,0.0003516375,0.0002538009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000368341,"about_ca_system_score_gemma":0.0002227748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000871039,"about_ca_topic_score_gemma":0.0007902341,"domain_scores_codex":[0.9998648,0.00002970421,0.00001474789,0.00001762817,0.00003499056,0.00003805256],"domain_scores_gemma":[0.9999392,0.00001230613,0.00001646869,0.000006795753,0.000009599903,0.00001556256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000119021,0.00001198052,0.0001268753,0.000009206668,0.000002053212,0.00002488457,0.000006849885,0.00004665248,0.9994228,0.00005253138,0.00001075656,0.0001664324],"study_design_scores_gemma":[0.000007500855,0.00009332576,0.002671723,0.000001236658,0.00000373161,0.000142538,0.00001654518,0.001265779,0.9954346,0.00001722896,0.0003437334,0.00000215119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979218,0.0003998457,0.0008476361,0.00005275077,0.000005732656,0.000009177441,0.0001797381,0.00001318352,0.0005701878],"genre_scores_gemma":[0.9978339,0.0001642807,0.0007200742,0.00002172332,0.000003518191,0.000008569738,0.0003744911,0.000005312396,0.0008681513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000871039,"threshold_uncertainty_score":0.002672493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.024644373714398,"score_gpt":0.2893491189857487,"score_spread":0.2647047452713507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}