{"id":"W3212241519","doi":"10.1182/blood-2021-150641","title":"Super-Enhancer Driven Regulation of CKS1B in Multiple Myeloma: Implications in Mediating Response to BET Inhibitor and Celmod Agent Combination","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Bromodomain; BRD4; Multiple myeloma; Cancer research; BET inhibitor; Enhancer; Biology; Medicine; Molecular biology; Internal medicine; Gene; Gene expression; Genetics; Epigenetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002690999,0.0001893784,0.0003676754,0.000266227,0.0002178535,0.0004388677,0.0001725816,0.0001747263,0.003318975],"category_scores_gemma":[0.0002523272,0.000153167,0.0003225496,0.0002864551,0.0002408256,0.0001639872,0.0003335578,0.000597005,0.0005922215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006476472,"about_ca_system_score_gemma":0.0003638996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001462607,"about_ca_topic_score_gemma":0.002512277,"domain_scores_codex":[0.9997371,0.0000154854,0.00001195554,0.00008769438,0.0001009274,0.00004683707],"domain_scores_gemma":[0.9998909,0.00002252681,0.0000342671,0.00001118208,0.00001798757,0.00002311766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005182301,0.00004788324,0.005043434,0.000140543,0.00002428837,0.00003535143,0.00004088385,0.0005920033,0.9866706,0.0002030545,0.0007171184,0.005966772],"study_design_scores_gemma":[0.0001017021,0.000450942,0.1007435,0.00004073748,0.0000984626,0.0003219435,0.0001199654,0.008523578,0.8735576,0.0003483629,0.01566169,0.00003142151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821716,0.003272386,0.003462402,0.0002695494,0.00008348946,0.00003914841,0.007951098,0.0003059217,0.002444438],"genre_scores_gemma":[0.9888499,0.0008214604,0.002485095,0.0001755604,0.00001162603,0.00005896605,0.0054576,0.00005897612,0.002080807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003318975,"threshold_uncertainty_score":0.01110303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02636046732419182,"score_gpt":0.3021907183115276,"score_spread":0.2758302509873358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}