{"id":"W3212241914","doi":"10.1182/blood-2021-150965","title":"Newly Developed Oncolytic Herpes Simplex Viruses Expressing Multiple Immunomodulatory Transgenes Effectively Target AML Cells","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada); Terry Fox Research Institute; University of British Columbia","funders":"","keywords":"Oncolytic virus; Herpes simplex virus; Myeloid leukemia; Multiplicity of infection; Biology; Leukemia; Virology; Cancer research; Immune system; Immunology; Medicine; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001282124,0.0003038403,0.00023638,0.0001499044,0.00006887319,0.0003280393,0.0001865994,0.0002184261,0.0005192514],"category_scores_gemma":[0.0001077293,0.00008063916,0.0001668176,0.0001264219,0.0001838247,0.0002134632,0.0001603767,0.0005884274,0.0001383887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002506318,"about_ca_system_score_gemma":0.0001559871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004024196,"about_ca_topic_score_gemma":0.0003761377,"domain_scores_codex":[0.9998831,0.00001548477,0.00001649059,0.00001968841,0.00003703298,0.00002821999],"domain_scores_gemma":[0.9999256,0.00001918036,0.00002018583,0.00001005511,0.00000928567,0.00001574423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008005472,0.00003490301,0.0002019892,0.00002293739,0.000004463161,0.00002194954,0.00001597862,0.0001817175,0.9979604,0.0001207549,0.00002114628,0.001333582],"study_design_scores_gemma":[0.00001322623,0.000464302,0.0007859183,0.000002596472,0.00001001902,0.00009727608,0.00001242426,0.001021421,0.9962464,0.00002949665,0.001314917,0.000002061901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957778,0.0008301697,0.002529927,0.00002849236,0.00002018612,0.000030401,0.0001368085,0.00004005976,0.0006060766],"genre_scores_gemma":[0.9943498,0.0005439687,0.003609007,0.00001797363,0.000006392105,0.00002264565,0.0003900781,0.000009999788,0.001050264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005192514,"threshold_uncertainty_score":0.001818538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02547431277016976,"score_gpt":0.2926691028579192,"score_spread":0.2671947900877495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}