{"id":"W3212247538","doi":"10.7554/elife.71473.sa1","title":"Decision letter: Disturbed retinoid metabolism upon loss of rlbp1a impairs cone function and leads to subretinal lipid deposits and photoreceptor degeneration in the zebrafish retina","year":2021,"lang":"en","type":"peer-review","venue":"","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Zebrafish; Biology; Retinitis pigmentosa; Retina; Visual phototransduction; Retinal pigment epithelium; Retinal degeneration; Dystrophy; Genetics; Retinal; Cell biology; Mutant; Opsin; Electroretinography; Retinoid; Phenotype; Rhodopsin; Neuroscience; Gene; Biochemistry; Retinoic acid","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002970955,0.0005462405,0.0008104147,0.0006103407,0.001686321,0.002479306,0.001658575,0.01161258,0.05946115],"category_scores_gemma":[0.01396893,0.0005239057,0.001094075,0.0003058754,0.001014171,0.001341322,0.001309785,0.005351641,0.03279484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002019138,"about_ca_system_score_gemma":0.002896963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001680741,"about_ca_topic_score_gemma":0.002564093,"domain_scores_codex":[0.9974995,0.0004374972,0.000394964,0.000248943,0.000914503,0.0005044567],"domain_scores_gemma":[0.9947266,0.001395206,0.0004112255,0.0003779062,0.001764662,0.001324278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002188202,0.00007170745,0.0004233079,0.00007609218,0.000009362717,0.001088252,0.00002837785,0.00004278831,0.0007371714,0.001281774,0.982723,0.01329944],"study_design_scores_gemma":[0.0002008185,0.0001661557,0.001567798,0.0002704606,0.00002155121,0.001575099,0.0001294286,0.0006534248,0.002097908,0.003325417,0.9899405,0.00005145469],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.008214767,0.001570302,0.002836348,0.5734184,0.3348364,0.001052863,0.004113067,0.001818707,0.07213915],"genre_scores_gemma":[0.06783543,0.004421742,0.00986212,0.5474405,0.138678,0.001152819,0.004364908,0.001002418,0.225242],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.05946115,"threshold_uncertainty_score":0.1989173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008431795651472593,"score_gpt":0.2467655487976147,"score_spread":0.2383337531461421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}