{"id":"W3212268582","doi":"10.1016/j.euo.2021.10.005","title":"Tissue- and Blood-derived Genomic Biomarkers for Metastatic Hormone-sensitive Prostate Cancer: A Systematic Review","year":2021,"lang":"en","type":"review","venue":"European Urology Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Janssen Pharmaceuticals; National Cancer Institute; National Institutes of Health; RefleXion Medical; Ipsen; Stand Up To Cancer; Ferring Pharmaceuticals; Prostate Cancer Foundation; AstraZeneca; Movember Foundation; Merck; Bayer; Kom op tegen Kanker; Astellas Pharma US; Pfizer","keywords":"Medicine; Disease; Biomarker; Prostate cancer; Oncology; Clinical trial; Internal medicine; Cancer; Bioinformatics; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002476671,0.001173714,0.005996909,0.003280438,0.0002397419,0.001536832,0.001518538,0.001419277,0.004479554],"category_scores_gemma":[0.010107,0.0006109026,0.007591199,0.00430392,0.0005016596,0.001406325,0.001072384,0.001046566,0.0003616011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009518457,"about_ca_system_score_gemma":0.002936181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005934174,"about_ca_topic_score_gemma":0.01867865,"domain_scores_codex":[0.998869,0.0003245326,0.000348614,0.0002001365,0.000201947,0.00005568701],"domain_scores_gemma":[0.9953194,0.003598619,0.0007153959,0.00006717847,0.0002410445,0.00005826612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0006428082,0.00003317715,0.002459451,0.8229284,0.03580778,0.0001044873,0.0001106064,0.0002890734,0.0003089652,0.0003284191,0.004514946,0.1324719],"study_design_scores_gemma":[0.00111262,0.0005411269,0.01770131,0.5292039,0.3912353,0.0006926368,0.0003374173,0.0002491966,0.0003983847,0.001152556,0.05723538,0.0001402195],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003033304,0.9992805,0.00005102311,0.00006286978,0.00003661071,0.00002180252,0.0001711411,0.000002454758,0.00007029407],"genre_scores_gemma":[0.005827328,0.9933217,0.0002112796,0.0003307146,0.00004454652,0.00003678642,0.0001677848,0.000001884896,0.00005789662],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005996909,"threshold_uncertainty_score":0.01498562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06133329220559403,"score_gpt":0.3943840527493043,"score_spread":0.3330507605437103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}