{"id":"W3212300774","doi":"10.1016/j.devcel.2021.10.018","title":"1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development","year":2021,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Yale Liver Center; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; University of Georgia; Fondation pour la Recherche Médicale; National Natural Science Foundation of China; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche; National Cancer Institute; Yale School of Medicine; Cancer Research UK; Yale University","keywords":"Biology; Lymphatic system; Cell biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002572256,0.0003042666,0.0002958546,0.00009240524,0.0001985855,0.00009104956,0.0001925451,0.0001308567,0.00005116532],"category_scores_gemma":[0.00004098743,0.0003267332,0.00006556829,0.000257477,0.00002351561,0.000008116197,0.00050239,0.00006763601,0.0001707187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006400927,"about_ca_system_score_gemma":0.0004058397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000165244,"about_ca_topic_score_gemma":0.00001151765,"domain_scores_codex":[0.9981443,0.00004708701,0.0003545698,0.0007012605,0.0002610811,0.0004917079],"domain_scores_gemma":[0.999151,0.00001367096,0.00005141125,0.0002545162,0.0001051204,0.0004242863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003342278,0.00006456009,0.003966692,0.00006039481,0.00003936415,0.0000131916,0.00121169,0.0000875862,0.9892174,0.00001115678,0.001771073,0.003523454],"study_design_scores_gemma":[0.0004920333,0.00003173536,0.007748482,0.000020994,0.00001473362,0.000009177889,0.0004154318,0.0000073756,0.8049846,0.000005013168,0.1858517,0.0004187695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936034,0.001479164,0.001064474,0.00007640765,0.0005231114,0.0002780823,0.00001697966,0.00002260227,0.002935771],"genre_scores_gemma":[0.9530034,0.0001099915,0.03939182,0.001506383,0.0002274576,0.00005520006,0.0001686404,0.00005363462,0.005483455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1842328,"threshold_uncertainty_score":0.9999185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00668471629709862,"score_gpt":0.2060580507045102,"score_spread":0.1993733344074115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}