{"id":"W3212303742","doi":"10.1182/blood-2021-147915","title":"Updated Results from MajesTEC-1: Phase 1/2 Study of Teclistamab, a B-Cell Maturation Antigen x CD3 Bispecific Antibody, in Relapsed/Refractory Multiple Myeloma","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Multiple myeloma; Antibody; Medicine; Antigen; Refractory (planetary science); Immunology; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006263182,0.001057021,0.002017914,0.0007191823,0.0004876053,0.001534748,0.001143041,0.001082135,0.002770688],"category_scores_gemma":[0.003519872,0.0004692032,0.001583006,0.0009257804,0.0002669577,0.0006860835,0.0006498889,0.002018632,0.0008813441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001050196,"about_ca_system_score_gemma":0.002025597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00216498,"about_ca_topic_score_gemma":0.005106977,"domain_scores_codex":[0.998174,0.0007871044,0.0002032995,0.0001679491,0.000471709,0.0001959975],"domain_scores_gemma":[0.9968683,0.0006350941,0.0009154491,0.0002556564,0.0007398017,0.0005857737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2493139,0.01790663,0.07959759,0.005184157,0.009930712,0.001356547,0.0007297553,0.006718569,0.1086827,0.0003945499,0.1076503,0.4125346],"study_design_scores_gemma":[0.1770542,0.2606406,0.3874741,0.0007893316,0.01482335,0.004035645,0.0002489576,0.002546529,0.02779796,0.0006086193,0.1237318,0.0002489521],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8563751,0.03050915,0.003565159,0.003312069,0.0006796226,0.006912056,0.08236351,0.000706657,0.01557662],"genre_scores_gemma":[0.7616709,0.0130418,0.009864407,0.007817693,0.0007385468,0.005269676,0.1942554,0.0003079617,0.007033556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006263182,"threshold_uncertainty_score":0.03312325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02954494550886255,"score_gpt":0.3206302640846435,"score_spread":0.291085318575781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}