{"id":"W3212303755","doi":"10.1016/j.molcel.2021.10.026","title":"Parp1 promotes sleep, which enhances DNA repair in neurons","year":2021,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":111,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Mental Health; Achelis Foundation; Azrieli Foundation; Israel Science Foundation; Division of Graduate Education; United States-Israel Binational Science Foundation; European Research Council; National Institutes of Health; National Science Foundation","keywords":"Biology; PARP1; DNA repair; Poly ADP ribose polymerase; DNA damage; Cell biology; Zebrafish; Sleep deprivation; Sleep (system call); Polymerase; Neuroscience; DNA; Circadian rhythm; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001770773,0.0003901618,0.000278202,0.0002759268,0.0003847189,0.0005030025,0.0003260977,0.0004074849,0.008135867],"category_scores_gemma":[0.0002859074,0.0002626472,0.0007282461,0.0001818365,0.0002756221,0.0004650665,0.0003712653,0.001104734,0.001054711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002910802,"about_ca_system_score_gemma":0.0003089601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005857292,"about_ca_topic_score_gemma":0.001263764,"domain_scores_codex":[0.9998953,0.00001310833,0.000009594806,0.00003392537,0.00001629638,0.00003177695],"domain_scores_gemma":[0.9997819,0.00002707569,0.00006175275,0.00003272284,0.00004051173,0.00005609647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001249338,0.0001536683,0.001045728,0.0004264876,0.0001044178,0.0001430823,0.00006861039,0.0001833638,0.9782037,0.001007111,0.001775413,0.01563912],"study_design_scores_gemma":[0.0001604051,0.001468103,0.04800987,0.00007814293,0.0001299936,0.000830469,0.0002826655,0.0007548494,0.9338084,0.001516318,0.01293332,0.00002745226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9432725,0.01816086,0.01637039,0.003010906,0.001345553,0.000108583,0.002858513,0.0009356341,0.01393717],"genre_scores_gemma":[0.981609,0.004688211,0.003111036,0.0005158114,0.0001456577,0.00005728945,0.001537882,0.00009133986,0.008243566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008135867,"threshold_uncertainty_score":0.02721715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02207668528627255,"score_gpt":0.2716922070683053,"score_spread":0.2496155217820328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}