{"id":"W3212309324","doi":"10.3390/ijns7040078","title":"The Alberta Newborn Screening Approach for Sickle Cell Disease: The Advantages of Molecular Testing","year":2021,"lang":"en","type":"article","venue":"International Journal of Neonatal Screening","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; University of Alberta Hospital; University of Alberta","funders":"","keywords":"Newborn screening; Medicine; Sickle cell anemia; Pediatrics; Incidence (geometry); Thalassemia; Sickle cell trait; Disease; Anemia; Dried blood; Red blood cell; Hemoglobinopathy; Blood transfusion; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00101641,0.0003014811,0.0001725295,0.00242003,0.0005962987,0.0006691693,0.0005275088,0.0001822718,0.000798545],"category_scores_gemma":[0.001832825,0.0001110237,0.0001716755,0.001701773,0.0003224494,0.0001942863,0.0006352757,0.0002586645,0.0001579781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002135806,"about_ca_system_score_gemma":0.004492703,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.3612318,"about_ca_topic_score_gemma":0.5426629,"domain_scores_codex":[0.9990531,0.0001982128,0.0000551185,0.0001033748,0.0005009806,0.00008921797],"domain_scores_gemma":[0.9991517,0.0001220184,0.0001612849,0.00005557595,0.0003634689,0.0001459207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002385683,0.00008130015,0.8531764,0.00009339509,0.00005668201,0.001282473,0.0005187889,0.00056938,0.003659114,0.0008671421,0.003196035,0.1362608],"study_design_scores_gemma":[0.00002328325,0.0002045409,0.9776347,0.00008618441,0.00009971276,0.00414787,0.0004855813,0.002505798,0.001752549,0.0002781656,0.01275194,0.00002966245],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9562782,0.009352111,0.009719349,0.001314478,0.0001119041,0.0002422785,0.001879784,0.000243061,0.02085892],"genre_scores_gemma":[0.9768738,0.005094626,0.01377096,0.0006097756,0.00007421245,0.0000964702,0.001018237,0.00002880018,0.002433002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6387682,"threshold_uncertainty_score":0.7182584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0148986121104913,"score_gpt":0.2703405298721451,"score_spread":0.2554419177616538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}