{"id":"W3212313924","doi":"10.1182/blood-2021-146228","title":"Characterization of Bruton Tyrosine Kinase Inhibitor (BTKi)-Related Adverse Events in a Head-to-Head Trial of Acalabrutinib Versus Ibrutinib in Previously Treated Chronic Lymphocytic Leukemia (CLL)","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Medicine; Ibrutinib; Tolerability; Adverse effect; Internal medicine; Incidence (geometry); Cumulative incidence; Chronic lymphocytic leukemia; Gastroenterology; Surgery; Cohort; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007322854,0.000403843,0.001225607,0.0006912185,0.00003444965,0.000006768511,0.0002650213,0.000466597,0.0002127871],"category_scores_gemma":[0.001378806,0.0004108012,0.000252204,0.00264974,0.0001362699,0.0001629129,0.000234045,0.0004173444,0.00005837435],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.03080831,"about_ca_system_score_gemma":0.03323696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002499194,"about_ca_topic_score_gemma":0.001070599,"domain_scores_codex":[0.9953407,0.0003714186,0.001724541,0.0007843688,0.0009506078,0.0008283308],"domain_scores_gemma":[0.9977986,0.0002796108,0.0003992865,0.0008808997,0.0003210585,0.000320609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.09617039,0.004367338,0.005278324,0.001761464,0.0004105225,0.001328056,0.001352752,0.0004527984,0.8860611,0.00004012405,0.00001883152,0.002758251],"study_design_scores_gemma":[0.5735823,0.002756278,0.01723709,0.00252275,0.0002928032,0.00008411267,0.00005818966,0.003318926,0.3997477,0.000005461483,0.0001105181,0.0002838596],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960934,0.0004183988,0.000003024587,0.00008292728,0.0003651461,0.00259628,0.00004697647,0.00006224209,0.0003316281],"genre_scores_gemma":[0.9981182,0.0003032066,0.00007534112,0.0000355626,0.0001894858,0.0001390405,0.0005317284,0.00007901651,0.0005284835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4863134,"threshold_uncertainty_score":0.9998344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02485270191560354,"score_gpt":0.3096979181604436,"score_spread":0.2848452162448401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}