{"id":"W3212351387","doi":"10.1001/jamaoncol.2021.4337","title":"Treatment Selection in First-line Metastatic Renal Cell Carcinoma—The Contemporary Treatment Paradigm in the Age of Combination Therapy","year":2021,"lang":"en","type":"review","venue":"JAMA Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Renal cell carcinoma; Oncology; Clear cell renal cell carcinoma; Internal medicine; Targeted therapy; Immune checkpoint; Blockade; Biomarker; Immunotherapy; Cancer; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001808543,0.0005361501,0.001597004,0.001104,0.0002158574,0.001221158,0.0009665494,0.001331911,0.001671742],"category_scores_gemma":[0.002976988,0.0001960228,0.0006441999,0.001474766,0.0007494054,0.001547986,0.0004933616,0.002396708,0.000625083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001071458,"about_ca_system_score_gemma":0.001595007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00126787,"about_ca_topic_score_gemma":0.0024062,"domain_scores_codex":[0.9993626,0.0002935145,0.00008814986,0.00007306223,0.0001530794,0.00002957526],"domain_scores_gemma":[0.9981193,0.001345829,0.0002106887,0.00003259943,0.000240486,0.00005100772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007961025,0.00003364657,0.0001644358,0.01958805,0.0001905168,0.00007081405,0.0000662521,0.0006074455,0.0002193775,0.005680705,0.02985737,0.9434418],"study_design_scores_gemma":[0.00007905246,0.0002253981,0.001302539,0.02629028,0.0004330925,0.001400001,0.0001723542,0.0003696491,0.0002020359,0.007654601,0.9618371,0.0000339306],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005166118,0.9988191,0.00006882402,0.0006858293,0.0001230126,0.000002138872,0.000004150666,0.000002857008,0.0002424739],"genre_scores_gemma":[0.0008993121,0.9978236,0.000147597,0.0007276481,0.0002705762,0.000007116661,0.000008143868,0.000001519325,0.0001144796],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001808543,"threshold_uncertainty_score":0.009564579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1414151983976761,"score_gpt":0.3723387328481768,"score_spread":0.2309235344505007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}