{"id":"W3212400736","doi":"10.1182/blood-2021-150481","title":"Zebrafish Models Provide Novel Insights into the Disease Biology of Parn-Mutant Dyskeratosis Congenita and DNAJC21-Mutant Shwachman-Diamond Syndrome","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; AGADA Biosciences; Hospital for Sick Children; Agricultural Research Institute of Ontario","funders":"","keywords":"Dyskeratosis congenita; Biology; Zebrafish; Genetics; Cancer research; Gene; Telomere","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002943419,0.0008215233,0.0004116654,0.0007843075,0.0003965614,0.0005199778,0.0005762964,0.00121685,0.004606893],"category_scores_gemma":[0.0001904914,0.0003666825,0.0006027814,0.0001579025,0.0005656953,0.0005616265,0.0006535343,0.001425339,0.0008024283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007766089,"about_ca_system_score_gemma":0.0005410822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002813474,"about_ca_topic_score_gemma":0.005460906,"domain_scores_codex":[0.9997464,0.00002597685,0.00002175593,0.00006973485,0.00009704141,0.00003908116],"domain_scores_gemma":[0.9998714,0.00002121912,0.0000423402,0.00001308857,0.00001914093,0.00003277071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006981698,0.00002081068,0.0003050155,0.0001243775,0.00001403578,0.0008503551,0.00005246333,0.0003716744,0.9910927,0.00341814,0.0006079832,0.003072486],"study_design_scores_gemma":[0.0002158431,0.0006047197,0.01384937,0.0002076058,0.000226425,0.007987157,0.0003000537,0.01078665,0.8810911,0.003323323,0.08130301,0.0001046531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7986425,0.0163487,0.1356583,0.00476332,0.001046779,0.0004213483,0.008597308,0.003110458,0.03141141],"genre_scores_gemma":[0.9378797,0.005812828,0.03243769,0.0005204669,0.00006375783,0.0003380062,0.001569771,0.0003033043,0.02107462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004606893,"threshold_uncertainty_score":0.01541162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009089426180147289,"score_gpt":0.2172788982325932,"score_spread":0.208189472052446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}